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OA-Br-1
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Catalog No. T205523
Alias OA-Br-1, 3-O-(6-Bromo-D-mannosyl)-28-acylamino-n-caproate methyl oleanolic acid
OA-Br-1 is an orally active, selective inhibitor of PTP1B with an IC50 value of 7.08 μM. It induces apoptosis and exhibits broad-spectrum anti-cancer cell proliferation activity. OA-Br-1 exerts anti-breast cancer effects both in vitro and in vivo through the PTP1B/PI3K/AKT signaling pathway.
OA-Br-1
OA-Br-1
😃Good
Catalog No. T205523Alias OA-Br-1, 3-O-(6-Bromo-D-mannosyl)-28-acylamino-n-caproate methyl oleanolic acid
OA-Br-1 is an orally active, selective inhibitor of PTP1B with an IC50 value of 7.08 μM. It induces apoptosis and exhibits broad-spectrum anti-cancer cell proliferation activity. OA-Br-1 exerts anti-breast cancer effects both in vitro and in vivo through the PTP1B/PI3K/AKT signaling pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | OA-Br-1 is an orally active, selective inhibitor of PTP1B with an IC50 value of 7.08 μM. It induces apoptosis and exhibits broad-spectrum anti-cancer cell proliferation activity. OA-Br-1 exerts anti-breast cancer effects both in vitro and in vivo through the PTP1B/PI3K/AKT signaling pathway. |
| In vitro | OA-Br-1 exhibits strong inhibitory activity against PTP1B with an IC50 value of 7.08 μM, while its inhibitory effect on TCPTP is weaker, with an IC50 of 222.28 μM [1]. It inhibits the proliferation of breast cancer cells (MCF-7, MDA-MB-231, MDA-MB-453) in a concentration- and time-dependent manner, with IC50 values of 8.76, 18.13, and 22.34 μM at 72 hours, respectively [1]. OA-Br-1 (5-30 μM; 48 h) induces apoptosis in MCF-7 and MDA-MB-231 cells [1] and increases the thermal stability of PTP1B [1]. Additionally, OA-Br-1 reduces colony formation in these cells dose-dependently [1] and decreases protein levels of p-PI3K and p-AKT, indicating its antitumor activity through the PTP1B/PI3K/AKT pathway in breast cancer cells [1]. |
| In vivo | OA-Br-1 (30-60 mg/kg; oral administration; daily) exhibits antitumor effects in a BALB/c female nude mouse model with subcutaneously implanted MCF-7 cells by inhibiting the PTP1B/PI3K/AKT signaling pathway [1]. |
| Alias | OA-Br-1, 3-O-(6-Bromo-D-mannosyl)-28-acylamino-n-caproate methyl oleanolic acid |
| Molecular Weight | 808.92 |
| Formula | C43H70BrNO8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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