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Dirithromycin

Name: Dirithromycin
Brand: TargetMol
SKU: T0971
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0971Cas No. 62013-04-1

Alias LY237216, Diritromicina, Dirithromycinum, Dirithromycine, ASE 136

Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Dirithromycin

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Purity: 98.89%

Catalog No. T0971Alias LY237216, Diritromicina, Dirithromycinum, Dirithromycine, ASE 136Cas No. 62013-04-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$31	In Stock	In Stock
1 g	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.89%

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.
In vivo	At therapeutic concentrations, Dirithromycin enhances the production of IL1β in cells stimulated by lipopolysaccharides, with increases of +37% and +28% at 1 μg/mL. At supra-therapeutic concentrations, Dirithromycin inhibits IL1β through the inhibition of protein kinase C; the concentration of Dirithromycin when 50% inhibition is achieved is 378 mg/mL, while for Spiramycin it is 234 mg/mL.
Synonyms	LY237216, Diritromicina, Dirithromycinum, Dirithromycine, ASE 136

Chemical Properties

Molecular Weight	835.07
Formula	C₄₂H₇₈N₂O₁₄
Cas No.	62013-04-1
Smiles	C[C@@H]1[C@]2(O[C@H](COCCOC)N[C@]1([C@H](C)C[C@@](C)(O)[C@H](O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@@H](C)[C@H](O[C@H]4C[C@](OC)(C)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O)[H])[H]
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 2.09 mg/mL (2.5 mM), Sonication is recommended.

Ethanol: 93 mg/mL (111.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.1975 mL	5.9875 mL	11.9750 mL	59.8752 mL

Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.2395 mL	1.1975 mL	2.3950 mL	11.9750 mL
10 mM	0.1198 mL	0.5988 mL	1.1975 mL	5.9875 mL
20 mM	0.0599 mL	0.2994 mL	0.5988 mL	2.9938 mL
50 mM	0.0240 mL	0.1198 mL	0.2395 mL	1.1975 mL
100 mM	0.0120 mL	0.0599 mL	0.1198 mL	0.5988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc