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PF-00217830
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Catalog No. T24613Cas No. 846032-02-8
Alias PF-217830
PF-00217830 is a serotonin 1A receptor agonist, dopamine D2 receptor agonist, and serotonin 2A receptor antagonist.PF-00217830 may be used in the study of schizophrenia.
PF-00217830
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Purity: 98.72%
Catalog No. T24613Alias PF-217830Cas No. 846032-02-8
PF-00217830 is a serotonin 1A receptor agonist, dopamine D2 receptor agonist, and serotonin 2A receptor antagonist.PF-00217830 may be used in the study of schizophrenia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $86 | In Stock | In Stock | |
| 5 mg | $216 | In Stock | In Stock | |
| 10 mg | $318 | In Stock | In Stock | |
| 25 mg | $515 | In Stock | In Stock | |
| 50 mg | $747 | In Stock | In Stock | |
| 100 mg | $1,050 | In Stock | In Stock | |
| 200 mg | $1,420 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.72%
Appearance:Solid
Color:White
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Product Introduction
PF-00217830 AI Summary
PF-00217830 exhibits bioactivities related to both dopaminergic and serotonergic systems, showing selectivity for the human D2 receptor over the 5-HT2A receptor. It exhibits moderate to strong inhibition effects and has intrinsic activity at these receptors. The compound demonstrates antipsychotic activity, as evidenced by its ability to reduce catalepsy and inhibit locomotor activity in mice. Furthermore, it functions as an antagonist at the 5-HT2A receptor in rats, with varying levels of inhibition observed at different doses. Pharmacokinetic data indicate favorable oral bioavailability, reasonable clearance, and distribution profiles in both rats and rhesus monkeys, with longer half-lives in the latter..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PF-00217830 is a serotonin 1A receptor agonist, dopamine D2 receptor agonist, and serotonin 2A receptor antagonist.PF-00217830 may be used in the study of schizophrenia. |
| Synonyms | PF-217830 |
| Molecular Weight | 430.54 |
| Formula | C26H30N4O2 |
| Cas No. | 846032-02-8 |
| Smiles | C(CCCOC=1NC=2C(=CC1)CCC(=O)N2)N3CCN(C=4C5=C(C=CC4)C=CC=C5)CC3 |
| Relative Density. | 1.25 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble)  H2O: < 1 mg/mL (insoluble or slightly soluble) |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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