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Anti-CCR2/CD192 Antibody (3O968)
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Catalog No. TMAY-00161
Alias PCLUD, MCP-1-R, FLJ78302, CMKBR2, CKR2B, CKR2A, CKR2, CD192, CCR2B, CCR2A, CCR-2, CC-CKR-2
Anti-CCR2/CD192 Antibody (3O968) is a Mouse antibody targeting CCR2/CD192. Anti-CCR2/CD192 Antibody (3O968) can be used in FCM.
Anti-CCR2/CD192 Antibody (3O968)
Anti-CCR2/CD192 Antibody (3O968)
😃Good
Catalog No. TMAY-00161Alias PCLUD, MCP-1-R, FLJ78302, CMKBR2, CKR2B, CKR2A, CKR2, CD192, CCR2B, CCR2A, CCR-2, CC-CKR-2
Anti-CCR2/CD192 Antibody (3O968) is a Mouse antibody targeting CCR2/CD192. Anti-CCR2/CD192 Antibody (3O968) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | PCLUD, MCP-1-R, FLJ78302, CMKBR2, CKR2B, CKR2A, CKR2, CD192, CCR2B, CCR2A, CCR-2, CC-CKR-2 |
| Ig Type | Mouse IgG1 |
| Clone | 3O968 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD192 expression on human whole blood monocytes. Cells were stained with purified anti-Human CD192, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human CCR2/CD192. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The C-C motif chemokine receptor-2 (CCR2) is a G protein-coupled receptor (GPCR), made up of a carboxy-terminus, extracellular amino terminus, and a hydrophobic transmembrane domain consisting of 7 amino acid segments that mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. CCR2 is expressed on monocytes, immature dendritic cells, and T-cell subpopulations, and mediates their migration towards endogenous CCL2. CCR2 is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. In mice, CCR2 deficiency reduced macrophage content, increased adiponectin expression, ameliorated hepatic steatosis, and improved systemic glucose homeostasis and insulin sensitivity. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. Furthermore, CCR2 mRNA was highly expressed in prostate cancer (PCa) metastatic tissues compared with benign prostate tissues according to real-time RT-PCR3, suggesting that CCR2 may contribute to PCa development. |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | A synthetic peptide: center region of the Human CCR2/CD192 |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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