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MS4078

Name: MS4078
Brand: TargetMol
SKU: T16153
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16153Cas No. 2229036-62-6

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

MS4078

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Purity: 98.74%

Catalog No. T16153Cas No. 2229036-62-6

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
2 mg	$64	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$683	-	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.74%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
Targets&IC50	ALK:33 nM(SU-DHL-1 cells), EML4-ALK:59 nM(DC50)(NCI-H2228 cells), NPM-ALK:11 nM(DC50)(SU-DHL-1 cells)
In vitro	MS4078 effectively inhibits cancer cell proliferation by inducing ALK protein degradation via a cereblon and proteasome-dependent mechanism. In SU-DHL-1 cells, it shows an IC50 of 33 nM, and potently reduces ALK fusion protein levels, inhibits ALK auto-phosphorylation, and downstream STAT3 phosphorylation in a concentration-dependent manner. It specifically reduces NPM-ALK protein levels in SU-DHL-1 cells (DC50 of 11 nM) and EML4-ALK protein levels in NCI-H2228 cells (DC50 of 59 nM).

Chemical Properties

Molecular Weight	914.47
Formula	C₄₅H₅₂ClN₉O₈S
Cas No.	2229036-62-6
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCNC(CN4CCC(CC4)C5=CC(OC(C)C)=C(NC=6N=C(NC7=C(S(C(C)C)(=O)=O)C=CC=C7)C(Cl)=CN6)C=C5C)=O
Relative Density.	1.377 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (164.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0935 mL	5.4676 mL	10.9353 mL	54.6765 mL
5 mM	0.2187 mL	1.0935 mL	2.1871 mL	10.9353 mL
10 mM	0.1094 mL	0.5468 mL	1.0935 mL	5.4676 mL
20 mM	0.0547 mL	0.2734 mL	0.5468 mL	2.7338 mL
50 mM	0.0219 mL	0.1094 mL	0.2187 mL	1.0935 mL
100 mM	0.0109 mL	0.0547 mL	0.1094 mL	0.5468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc