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MS4078

Name: MS4078
Brand: TargetMol
SKU: T16153
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16153Cas No. 2229036-62-6

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

MS4078

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Purity: 98.74%

Catalog No. T16153Cas No. 2229036-62-6

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

Pack Size	Price	Availability
1 mg	$44	In Stock
2 mg	$64	In Stock
5 mg	$97	In Stock
10 mg	$163	In Stock
25 mg	$289	In Stock
50 mg	$463	In Stock
100 mg	$683	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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Purity:98.74%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
Targets&IC50	ALK:33 nM(SU-DHL-1 cells), NPM-ALK:11 nM(DC50)(SU-DHL-1 cells), EML4-ALK:59 nM(DC50)(NCI-H2228 cells)
In vitro	MS4078 effectively inhibits cancer cell proliferation by inducing ALK protein degradation via a cereblon and proteasome-dependent mechanism. In SU-DHL-1 cells, it shows an IC50 of 33 nM, and potently reduces ALK fusion protein levels, inhibits ALK auto-phosphorylation, and downstream STAT3 phosphorylation in a concentration-dependent manner. It specifically reduces NPM-ALK protein levels in SU-DHL-1 cells (DC50 of 11 nM) and EML4-ALK protein levels in NCI-H2228 cells (DC50 of 59 nM).

Chemical Properties

Molecular Weight	914.47
Formula	C₄₅H₅₂ClN₉O₈S
Cas No.	2229036-62-6
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCNC(CN4CCC(CC4)C5=CC(OC(C)C)=C(NC=6N=C(NC7=C(S(C(C)C)(=O)=O)C=CC=C7)C(Cl)=CN6)C=C5C)=O
Relative Density.	1.377 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49 mg/mL (53.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0935 mL	5.4676 mL	10.9353 mL	54.6765 mL
5 mM	0.2187 mL	1.0935 mL	2.1871 mL	10.9353 mL
10 mM	0.1094 mL	0.5468 mL	1.0935 mL	5.4676 mL
20 mM	0.0547 mL	0.2734 mL	0.5468 mL	2.7338 mL
50 mM	0.0219 mL	0.1094 mL	0.2187 mL	1.0935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc