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MS4078

MS4078
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
Catalog No. T16153Cas No. 2229036-62-6
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Purity:98.74%
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MS4078

Purity: 98.74%
Catalog No. T16153Cas No. 2229036-62-6

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
2 mg$64In Stock
5 mg$97In Stock
10 mg$163In Stock
25 mg$289In Stock
50 mg$463In Stock
100 mg$683In Stock
1 mL x 10 mM (in DMSO)$163In Stock
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Product Introduction

Bioactivity
Description
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
Targets&IC50
EML4-ALK:59 nM(DC50)(NCI-H2228 cells), NPM-ALK:11 nM(DC50)(SU-DHL-1 cells), ALK:33 nM(SU-DHL-1 cells)
In vitro
MS4078 effectively inhibits cancer cell proliferation by inducing ALK protein degradation via a cereblon and proteasome-dependent mechanism. In SU-DHL-1 cells, it shows an IC50 of 33 nM, and potently reduces ALK fusion protein levels, inhibits ALK auto-phosphorylation, and downstream STAT3 phosphorylation in a concentration-dependent manner. It specifically reduces NPM-ALK protein levels in SU-DHL-1 cells (DC50 of 11 nM) and EML4-ALK protein levels in NCI-H2228 cells (DC50 of 59 nM).
Chemical Properties
Molecular Weight914.47
FormulaC45H52ClN9O8S
Cas No.2229036-62-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 49 mg/mL (53.58 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0935 mL5.4676 mL10.9353 mL54.6765 mL
5 mM0.2187 mL1.0935 mL2.1871 mL10.9353 mL
10 mM0.1094 mL0.5468 mL1.0935 mL5.4676 mL
20 mM0.0547 mL0.2734 mL0.5468 mL2.7338 mL
50 mM0.0219 mL0.1094 mL0.2187 mL1.0935 mL

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