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Ro 20-1724

🥰Excellent
Catalog No. T19706Cas No. 29925-17-5
Alias Ro20-1724, Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.

Ro 20-1724

Ro 20-1724

🥰Excellent
Purity: 99.79%
Catalog No. T19706Alias Ro20-1724, Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinoneCas No. 29925-17-5
Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$40In StockIn Stock
10 mg$64In StockIn Stock
25 mg$128In StockIn Stock
50 mg$187In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.79%
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Product Introduction

Bioactivity
Description
Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.
Targets&IC50
PDE4:2.0 μM, PDE4:3.1 μM(Ki)
In vivo
RO-20-1724 was found to not only improve learning and memory in MWM and PA paradigms but also restore STZ induced elevation in cholinesterase activity. Further, RO-20-1724 significantly reduced malondialdehyde and nitrite levels, and restored the glutathione levels indicating attenuation of oxidative stress[2].
SynonymsRo20-1724, Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Chemical Properties
Molecular Weight278.35
FormulaC15H22N2O3
Cas No.29925-17-5
SmilesCCCCOC1=C(OC)C=CC(CC2CNC(=O)N2)=C1
Relative Density.1.099 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (179.63 mM), Sonication is recommended.
Ethanol: 50 mg/mL (179.63 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.19 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.5926 mL17.9630 mL35.9260 mL179.6300 mL
5 mM0.7185 mL3.5926 mL7.1852 mL35.9260 mL
10 mM0.3593 mL1.7963 mL3.5926 mL17.9630 mL
20 mM0.1796 mL0.8981 mL1.7963 mL8.9815 mL
50 mM0.0719 mL0.3593 mL0.7185 mL3.5926 mL
100 mM0.0359 mL0.1796 mL0.3593 mL1.7963 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ro 20-174Ro 20-1724Ro 201724Ro 20 1724Phosphodiesterase (PDE)phosphodiesterasePDE4neuroprotectiveInhibitorinhibitcognitivecAMPantioxidant
Related Tags: buy Ro 20-1724 | purchase Ro 20-1724 | Ro 20-1724 cost | order Ro 20-1724 | Ro 20-1724 chemical structure | Ro 20-1724 in vivo | Ro 20-1724 formula | Ro 20-1724 molecular weight
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