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Benzethonium chloride

Name: Benzethonium chloride
Brand: TargetMol
SKU: T0401
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0401Cas No. 121-54-0

Alias Quatrachlor, Phemeride, Hyamine

Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.

Benzethonium chloride

🥰Excellent

Purity: 99.91%

Catalog No. T0401Alias Quatrachlor, Phemeride, HyamineCas No. 121-54-0

Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$48	In Stock	In Stock
1 g	$68	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Questions

Batch Information

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Purity:99.91%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
Targets&IC50	α7 nAChR:122 nM, α4β2 nAChR:49 nM
In vitro	Administered in SCID mice bearing human laryngeal squamous cell carcinoma tumors, Benzethonium chloride (5 mg/kg) inhibited the growth of xenografts.
In vivo	In human hypopharyngeal squamous carcinoma cells, Benzethonium chloride at a concentration of 9 µM induces apoptosis and activates caspases after 12 hours. Furthermore, Benzethonium chloride at 5 µM enhances the effect of glucose consumption on the intracellular solute Ca(2+) concentration and its binding to membrane-associated proteins.
Cell Research	Cells are seeded in 96-well plates at 5,000 per well in 100 μL of growth medium and allowed to incubate for 24 hours. Benzethonium chloride is then added, as indicated, in a total volume of 5 μL. After 48 hours, MTS assay is done according to the specifications of the manufacturer, with DMSO (0.1%)–treated cells as negative control and cisplatin (166.6 μM)–treated cells as positive control.(Only for Reference)
Synonyms	Quatrachlor, Phemeride, Hyamine

Chemical Properties

Molecular Weight	448.09
Formula	C₂₇H₄₂ClNO₂
Cas No.	121-54-0
Smiles	[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1
Relative Density.	1.1. Temperature:20 °C.
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (100.43 mM), Sonication is recommended.

H2O: 83 mg/mL (185.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2317 mL	11.1585 mL	22.3169 mL	111.5847 mL
5 mM	0.4463 mL	2.2317 mL	4.4634 mL	22.3169 mL
10 mM	0.2232 mL	1.1158 mL	2.2317 mL	11.1585 mL
20 mM	0.1116 mL	0.5579 mL	1.1158 mL	5.5792 mL
50 mM	0.0446 mL	0.2232 mL	0.4463 mL	2.2317 mL
100 mM	0.0223 mL	0.1116 mL	0.2232 mL	1.1158 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc