Shopping Cart

Your shopping cart is currently empty

Benzethonium chloride

Name: Benzethonium chloride
Brand: TargetMol
SKU: T0401
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T0401Cas No. 121-54-0

Alias Quatrachlor, Phemeride, Hyamine

Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.

Benzethonium chloride

😃Good

Purity: 99.91%

Catalog No. T0401Alias Quatrachlor, Phemeride, HyamineCas No. 121-54-0

Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$48	In Stock	In Stock
1 g	$68	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
Targets&IC50	α7 nAChR:122 nM, α4β2 nAChR:49 nM
In vitro	In human hypopharyngeal squamous carcinoma cells, Benzethonium chloride at a concentration of 9 µM induces apoptosis and activates caspases after 12 hours. Furthermore, Benzethonium chloride at 5 µM enhances the effect of glucose consumption on the intracellular solute Ca(2+) concentration and its binding to membrane-associated proteins.
In vivo	Administered in SCID mice bearing human laryngeal squamous cell carcinoma tumors, Benzethonium chloride (5 mg/kg) inhibited the growth of xenografts.
Cell Research	Cells are seeded in 96-well plates at 5,000 per well in 100 μL of growth medium and allowed to incubate for 24 hours. Benzethonium chloride is then added, as indicated, in a total volume of 5 μL. After 48 hours, MTS assay is done according to the specifications of the manufacturer, with DMSO (0.1%)–treated cells as negative control and cisplatin (166.6 μM)–treated cells as positive control.(Only for Reference)
Synonyms	Quatrachlor, Phemeride, Hyamine

Chemical Properties

Molecular Weight	448.09
Formula	C₂₇H₄₂ClNO₂
Cas No.	121-54-0
Smiles	[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1
Relative Density.	1.1. Temperature:20 °C.

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (100.43 mM), Sonication is recommended.

H2O: 83 mg/mL (185.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2317 mL	11.1585 mL	22.3169 mL	111.5847 mL
5 mM	0.4463 mL	2.2317 mL	4.4634 mL	22.3169 mL
10 mM	0.2232 mL	1.1158 mL	2.2317 mL	11.1585 mL
20 mM	0.1116 mL	0.5579 mL	1.1158 mL	5.5792 mL
50 mM	0.0446 mL	0.2232 mL	0.4463 mL	2.2317 mL
100 mM	0.0223 mL	0.1116 mL	0.2232 mL	1.1158 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc