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Estradiol (cypionate)

Name: Estradiol (cypionate)
Brand: TargetMol
SKU: T0168
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0168Cas No. 313-06-4

Alias Estradiol cypionate, Depofemin

Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.

Estradiol (cypionate)

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Purity: 99.83%

Catalog No. T0168Alias Estradiol cypionate, DepofeminCas No. 313-06-4

Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$46	In Stock	In Stock
1 g	$79	In Stock	-
1 mL x 10 mM (in DMSO)	$51	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
In vivo	In the field of bovine medicine, Estradiol cypionate (ECP) serves a variety of functions, including the treatment of libido deficiency due to follicular cysts, persistent corpus luteum, pyometra, and retained placenta. ECP may also aid in mitigating high-risk postpartum diseases by stimulating uterine contractions (through direct action or by maintaining oxytocin receptor sites in the uterus); enhancing uterine immune function (by increasing uterine blood flow to attract more white blood cells (WBCs) to the site of infection and augmenting the movement of IgA and IgG for bacterial phagocytosis into the uterine cavity); and promoting uterine drainage (by delaying cervical closure). Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Intramuscular administration of estradiol cypionate has been found to have the longest duration of action compared to other commonly used estradiol esters, lasting for 11 days, while estradiol benzoate and estradiol valerate have durations of 4-5 days and 7-8 days, respectively.
Synonyms	Estradiol cypionate, Depofemin

Chemical Properties

Molecular Weight	396.56
Formula	C₂₆H₃₆O₃
Cas No.	313-06-4
Smiles	C[C@]12CCC3C(CCc4cc(O)ccc34)C1CC[C@@H]2OC(=O)CCC1CCCC1
Relative Density.	1.15g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 51 mg/mL (128.61 mM), Sonication is recommended.

DMSO: 257.5 mg/mL (649.33 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5217 mL	12.6084 mL	25.2169 mL	126.0843 mL
5 mM	0.5043 mL	2.5217 mL	5.0434 mL	25.2169 mL
10 mM	0.2522 mL	1.2608 mL	2.5217 mL	12.6084 mL
20 mM	0.1261 mL	0.6304 mL	1.2608 mL	6.3042 mL
50 mM	0.0504 mL	0.2522 mL	0.5043 mL	2.5217 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc