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Yadanzigan
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Catalog No. T73199Cas No. 76588-87-9
Alias YDZG
Yadanzigan (YDZG), a natural product from Brucea javanica and a specific NLRP3 inhibitor, attenuates the NF-κB pathway and reactive oxygen species generation in mitochondria, while enhancing TRIM31, which has anti-inflammatory effects and prevents lps-induced acute lung injury.
Yadanzigan
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Purity: 99.98%
Catalog No. T73199Alias YDZGCas No. 76588-87-9
Yadanzigan (YDZG), a natural product from Brucea javanica and a specific NLRP3 inhibitor, attenuates the NF-κB pathway and reactive oxygen species generation in mitochondria, while enhancing TRIM31, which has anti-inflammatory effects and prevents lps-induced acute lung injury.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $162 | - | In Stock | |
| 5 mg | $397 | - | In Stock | |
| 10 mg | $596 | - | In Stock | |
| 25 mg | $933 | - | In Stock | |
| 50 mg | $1,250 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
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| Description | Yadanzigan (YDZG), a natural product from Brucea javanica and a specific NLRP3 inhibitor, attenuates the NF-κB pathway and reactive oxygen species generation in mitochondria, while enhancing TRIM31, which has anti-inflammatory effects and prevents lps-induced acute lung injury. |
| In vitro | Yadanzigan (20–80 μM; 24 h) significantly inhibited LPS (1 μg/mL) + ATP (5 mM)–induced NLRP3 inflammasome activation in RAW264.7, J774A.1, and THP-1 macrophages, reducing caspase-1 and IL-1β expression/secretion, enhancing TRIM31 expression, and suppressing mitochondrial ROS production[1]. |
| In vivo | In LPS-induced acute lung injury (ALI) mouse models, intravenous administration of Yadanzigan (5 or 10 mg/kg) significantly reduced NLRP3 and caspase-1 expression in lung tissues, alleviated histopathological damage, lowered leukocyte infiltration and inflammatory cytokines (IL-1β, TNF-α, IL-6), and improved survival[1]. |
| Synonyms | YDZG |
| Molecular Weight | 574.57 |
| Formula | C26H38O14 |
| Cas No. | 76588-87-9 |
| Smiles | O=C1OC2CC3C(=CC(OC4OC(CO)C(O)C(O)C4O)C(O)C3(C)C5C(O)C(O)C6(OCC25C6(O)C1O)C)C |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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