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Selurampanel

🥰Excellent
Catalog No. T34609Cas No. 912574-69-7
Alias BGG-492, BGG492, BGG 492

Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus.

Selurampanel

Selurampanel

🥰Excellent
Purity: 99.78%
Catalog No. T34609Alias BGG-492, BGG492, BGG 492Cas No. 912574-69-7
Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$113In StockIn Stock
5 mg$269In StockIn Stock
10 mg$388In StockIn Stock
25 mg$598In StockIn Stock
50 mg$853-In Stock
100 mg$1,180-In Stock
1 mL x 10 mM (in DMSO)$281In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.78%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus.
Targets&IC50
AMPA:190 nM
In vivo
Selurampanel (3 mg/kg i.v.) a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min▪kg.[5]
Selurampanel potently and dose-dependently antagonizes maximal electroshock seizure-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment.[5]
SynonymsBGG-492, BGG492, BGG 492
Chemical Properties
Molecular Weight377.42
FormulaC16H19N5O4S
Cas No.912574-69-7
SmilesC(C)(C)C1=C(C=C2C(=C1)NC(=O)N(NS(C)(=O)=O)C2=O)C=3N(C)N=CC3
Relative Density.1.49 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 27.5 mg/mL (72.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6496 mL13.2478 mL26.4957 mL132.4784 mL
5 mM0.5299 mL2.6496 mL5.2991 mL26.4957 mL
10 mM0.2650 mL1.3248 mL2.6496 mL13.2478 mL
20 mM0.1325 mL0.6624 mL1.3248 mL6.6239 mL
50 mM0.0530 mL0.2650 mL0.5299 mL2.6496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

SelurampaneliGluR
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