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Antibacterial agent 122
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Catalog No. T60690Cas No. 109310-99-8
Antibacterial agent 122 (compound 15) is a thiourea derivative used in tuberculosis research, demonstrating low cytotoxicity and anti-mycobacterial activity [1].
Antibacterial agent 122
😃Good
Catalog No. T60690Cas No. 109310-99-8
Antibacterial agent 122 (compound 15) is a thiourea derivative used in tuberculosis research, demonstrating low cytotoxicity and anti-mycobacterial activity [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antibacterial agent 122 (compound 15) is a thiourea derivative used in tuberculosis research, demonstrating low cytotoxicity and anti-mycobacterial activity [1]. |
| In vitro | Antibacterial agent 122 (compound 15) (25-200 μM, 24 h) inhibits M. tuberculosis H37Rv with an MIC50 of 5.9 μM, reduces NO production in LPS-stimulated RAW 264.7 cells with an IC50 of 8.1 μM, scavenges NO with an IC50 of 184.2 μM, and nearly completely inhibits iNOS expression at 100 μM [1]. Additionally, at concentrations of 0-200 μM, it inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with IC50 values of 28.4 μM and 47.9 μM, respectively. Furthermore, at 25-100 μM over 4 days, it inhibits M. tuberculosis M299 with an MIC50 of 24.7 μM [1]. |
| Molecular Weight | 302.35 |
| Formula | C15H14N2O3S |
| Cas No. | 109310-99-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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