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KEA1-97

Name: KEA1-97
Brand: TargetMol
SKU: T9118
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9118Cas No. 2138882-71-8

Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin.

KEA1-97

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Purity: 97.07%

Catalog No. T9118Cas No. 2138882-71-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	-	In Stock
25 mg	$86	-	In Stock
50 mg	$137	-	In Stock
100 mg	$227	-	In Stock
200 mg	$335	-	In Stock
1 mL x 10 mM (in DMSO)	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.07%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin.
Targets&IC50	Caspase-3:10μM, Thiordoxine:10μM
In vitro	KEA1-97 (10 μM, 48h) impaired 231MFP cell survival and proliferation and does not affect viability in MCF10A cells.
In vivo	KEA1–97 treatment (5 mg/kg ip once per day) was initiated 16 days after the initiation of 231MFP tumor xenografts in immune-deficient SCID mice.

Chemical Properties

Molecular Weight	335.16
Formula	C₁₅H₉Cl₂FN₄
Cas No.	2138882-71-8
Smiles	Fc1ccc(cc1)-c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1
Relative Density.	1.466 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (268.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9836 mL	14.9182 mL	29.8365 mL	149.1825 mL
5 mM	0.5967 mL	2.9836 mL	5.9673 mL	29.8365 mL
10 mM	0.2984 mL	1.4918 mL	2.9836 mL	14.9182 mL
20 mM	0.1492 mL	0.7459 mL	1.4918 mL	7.4591 mL
50 mM	0.0597 mL	0.2984 mL	0.5967 mL	2.9836 mL
100 mM	0.0298 mL	0.1492 mL	0.2984 mL	1.4918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc