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7ACC2

Name: 7ACC2
Brand: TargetMol
SKU: T1768
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1768Cas No. 1472624-85-3

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.

7ACC2

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Purity: 99.66%

Catalog No. T1768Cas No. 1472624-85-3

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$47	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	$423	In Stock	In Stock
100 mg	$629	In Stock	In Stock
500 mg	$1,350	-	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.66%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

7ACC2 AI Summary

7ACC2 shows bioactivities related to lactate uptake, metabolism, and solubility. It inhibits MCT4-mediated lactate uptake in human SiHa cells, with IC50 values of 10.0 nM after 12 minutes and 59.0 nM after 24 hours. Additionally, it demonstrates cytotoxicity against human SiHa cells with an EC50 value of 220.0 nM. This compound exhibits favorable stability in various fluids and biological systems, such as simulated gastric fluid, simulated intestinal fluid, mouse plasma, and human plasma. It also has a relatively long half-life in both mouse and human liver microsomes. Furthermore, 7ACC2 boasts a high aqueous solubility of 58000.0 nM in PBS buffer at pH 7.4..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
Targets&IC50	MCT:11 nM

Chemical Properties

Molecular Weight	309.32
Formula	C₁₈H₁₅NO₄
Cas No.	1472624-85-3
Smiles	CN(Cc1ccccc1)c1ccc2cc(C(O)=O)c(=O)oc2c1
Relative Density.	1.368 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 35.71 mg/mL (115.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2329 mL	16.1645 mL	32.3290 mL	161.6449 mL
5 mM	0.6466 mL	3.2329 mL	6.4658 mL	32.3290 mL
10 mM	0.3233 mL	1.6164 mL	3.2329 mL	16.1645 mL
20 mM	0.1616 mL	0.8082 mL	1.6164 mL	8.0822 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL	3.2329 mL
100 mM	0.0323 mL	0.1616 mL	0.3233 mL	1.6164 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc