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VU0650786

Name: VU0650786
Brand: TargetMol
SKU: T13318
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13318Cas No. 1809085-30-0

VU0650786 is a selective and potent CNS-penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), exhibiting antidepressant and anxiolytic activity in rodents.

VU0650786

🥰Excellent

Purity: 99.09%

Catalog No. T13318Cas No. 1809085-30-0

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$247	In Stock
10 mg	$347	In Stock
25 mg	$589	In Stock
50 mg	$842	In Stock
100 mg	$1,160	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Batch Information

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Purity:99.09%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU0650786 is a selective and potent CNS-penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), exhibiting antidepressant and anxiolytic activity in rodents.
Targets&IC50	mGluR3:392 nM

Chemical Properties

Molecular Weight	387.8
Formula	C₁₈H₁₅ClFN₅O₂
Cas No.	1809085-30-0
Smiles	C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccnc1F
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: insoluble

DMSO: 240 mg/mL (618.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5786 mL	12.8932 mL	25.7865 mL	128.9324 mL
5 mM	0.5157 mL	2.5786 mL	5.1573 mL	25.7865 mL
10 mM	0.2579 mL	1.2893 mL	2.5786 mL	12.8932 mL
20 mM	0.1289 mL	0.6447 mL	1.2893 mL	6.4466 mL
50 mM	0.0516 mL	0.2579 mL	0.5157 mL	2.5786 mL
100 mM	0.0258 mL	0.1289 mL	0.2579 mL	1.2893 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc