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PP58

Name: PP58
Brand: TargetMol
SKU: T13824
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13824Cas No. 212391-58-7

PP58 is an inhibitor of PDGFR, FGFR and Src family.

PP58

🥰Excellent

Purity: 99.21%

Catalog No. T13824Cas No. 212391-58-7

PP58 is an inhibitor of PDGFR, FGFR and Src family.

Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$56	In Stock
10 mg	$88	In Stock
25 mg	$153	In Stock
50 mg	$238	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock

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Batch Information

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Purity:99.21%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PP58 is an inhibitor of PDGFR, FGFR and Src family.
In vitro	PP58 inhibits anisomycin-activated p38 in a dose-dependent manner with an IC50 < 10 nM. LPS-stimulated TNF-α production is potently inhibited by PP58 with a cellular IC50 value of 3 nM[1].
In vivo	PP58 exhibits some degree of selectivity in vivo[1].

Chemical Properties

Molecular Weight	456.32
Formula	C₂₂H₁₉Cl₂N₅O₂
Cas No.	212391-58-7
Smiles	Cn1c2nc(Nc3ccc(OCCN)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Relative Density.	1.426 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 56.3 mg/mL (123.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1914 mL	10.9572 mL	21.9144 mL	109.5722 mL
5 mM	0.4383 mL	2.1914 mL	4.3829 mL	21.9144 mL
10 mM	0.2191 mL	1.0957 mL	2.1914 mL	10.9572 mL
20 mM	0.1096 mL	0.5479 mL	1.0957 mL	5.4786 mL
50 mM	0.0438 mL	0.2191 mL	0.4383 mL	2.1914 mL
100 mM	0.0219 mL	0.1096 mL	0.2191 mL	1.0957 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc