Integrin-IN-2

Name: Integrin-IN-2
Brand: TargetMol
SKU: T11663
Rating: 4.5 (1 reviews)

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Catalog No. T11663Cas No. 2378617-67-3

Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.

Integrin-IN-2

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Catalog No. T11663Cas No. 2378617-67-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	6-8 weeks	6-8 weeks

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Product Introduction

Bioactivity

Description	Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.
Targets&IC50	αvβ6 integrin:7.8(pIC50), αvβ5 integrin:8.4, αvβ3 integrin:8.4, αvβ8 integrin:7.4
In vivo	In vivo pharmacokinetic studies conducted on CD rats have demonstrated that the racemic compound Integrin-IN-2 (compound 39) displays a low plasma clearance rate of 8 mL/(min·kg), coupled with a low to moderate distribution volume of 0.5 L/kg. It exhibits a moderate half-life of 1.8 hours and an exceptionally high bioavailability of 98%.

Chemical Properties

Molecular Weight	458.55
Formula	C₂₇H₃₀N₄O₃
Cas No.	2378617-67-3
Smiles	C(NC1=CC=C(OCCC=2NC=3C(=CC2)CCCN3)C=N1)(CC(O)=O)C=4C=C(C=CC4)C5CC5
Relative Density.	1.33 g/cm3 (Predicted)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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