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Pralidoxime Chloride

Name: Pralidoxime Chloride
Brand: TargetMol
SKU: T1111
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1111Cas No. 51-15-0

Alias 2-Pyridinealdoxime methochloride, 2-PAM chloride, 2-PAM (chloride)

Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents).

Pralidoxime Chloride

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Purity: 99.84%

Catalog No. T1111Alias 2-Pyridinealdoxime methochloride, 2-PAM chloride, 2-PAM (chloride)Cas No. 51-15-0

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
500 mg	$65	In Stock	In Stock
1 g	$95	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.84%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents).
In vitro	The application of pralidoxime allowed the regeneration of an important fraction of inhibited AChE, process which is concentration-dependent[1].
Synonyms	2-Pyridinealdoxime methochloride, 2-PAM chloride, 2-PAM (chloride)

Chemical Properties

Molecular Weight	172.61
Formula	C₇H₉ClN₂O
Cas No.	51-15-0
Smiles	C[n+]1ccccc1/C=N/O.[Cl-]
Relative Density.	1.3265 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (289.67 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7934 mL	28.9670 mL	57.9341 mL	289.6704 mL
5 mM	1.1587 mL	5.7934 mL	11.5868 mL	57.9341 mL
10 mM	0.5793 mL	2.8967 mL	5.7934 mL	28.9670 mL
20 mM	0.2897 mL	1.4484 mL	2.8967 mL	14.4835 mL
50 mM	0.1159 mL	0.5793 mL	1.1587 mL	5.7934 mL
100 mM	0.0579 mL	0.2897 mL	0.5793 mL	2.8967 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc