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Eleclazine

🥰Excellent
Catalog No. T71945Cas No. 1443211-72-0
Alias GS-6615, GS6615, Eleclazine free base

Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP) recorded from human induced pluripotent stem cell–derived cardiomyocytes.

Eleclazine

Eleclazine

🥰Excellent
Purity: 98.67%
Catalog No. T71945Alias GS-6615, GS6615, Eleclazine free baseCas No. 1443211-72-0
Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP) recorded from human induced pluripotent stem cell–derived cardiomyocytes.
Pack SizePriceAvailabilityQuantity
1 mg$40 In Stock
5 mg$90 In Stock
10 mg$135 In Stock
25 mg$230 In Stock
50 mg$420 In Stock
100 mg$710 In Stock
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Purity:98.67%
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Product Introduction

Bioactivity
Description
Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP) recorded from human induced pluripotent stem cell–derived cardiomyocytes.
In vitro
In isolated failing rabbit hearts with ischemia-reperfusion injury, Eleclazine (1 μM, 20 min perfusion) reduced APD dispersion and accelerated intracellular Ca²⁺ clearance, suppressing arrhythmogenic alternans. Under therapeutic hypothermia (33 °C, 30 min), Eleclazine further improved outcomes by reducing ventricular fibrillation (VF) inducibility and severity[1].
AliasGS-6615, GS6615, Eleclazine free base
Chemical Properties
Molecular Weight415.37
FormulaC21H16F3N3O3
Cas No.1443211-72-0
SmilesO=C1C2=CC(=CC=C2OCCN1CC3=NC=CC=N3)C=4C=CC(OC(F)(F)F)=CC4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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