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Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP) recorded from human induced pluripotent stem cell–derived cardiomyocytes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $40 | In Stock | |
5 mg | $90 | In Stock | |
10 mg | $135 | In Stock | |
25 mg | $230 | In Stock | |
50 mg | $420 | In Stock | |
100 mg | $710 | In Stock |
Description | Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP) recorded from human induced pluripotent stem cell–derived cardiomyocytes. |
In vitro | In isolated failing rabbit hearts with ischemia-reperfusion injury, Eleclazine (1 μM, 20 min perfusion) reduced APD dispersion and accelerated intracellular Ca²⁺ clearance, suppressing arrhythmogenic alternans. Under therapeutic hypothermia (33 °C, 30 min), Eleclazine further improved outcomes by reducing ventricular fibrillation (VF) inducibility and severity[1]. |
Alias | GS-6615, GS6615, Eleclazine free base |
Molecular Weight | 415.37 |
Formula | C21H16F3N3O3 |
Cas No. | 1443211-72-0 |
Smiles | O=C1C2=CC(=CC=C2OCCN1CC3=NC=CC=N3)C=4C=CC(OC(F)(F)F)=CC4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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