Eleclazine

Name: Eleclazine
Brand: TargetMol
SKU: T71945
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71945Cas No. 1443211-72-0

Alias GS-6615, GS6615, Eleclazine free base

Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP) recorded from human induced pluripotent stem cell–derived cardiomyocytes.

Eleclazine

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Purity: 98.67%

Catalog No. T71945Alias GS-6615, GS6615, Eleclazine free baseCas No. 1443211-72-0

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$90	In Stock
10 mg	$135	In Stock
25 mg	$230	In Stock
50 mg	$420	In Stock
100 mg	$710	In Stock

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Purity:98.67%

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Product Introduction

Bioactivity

Description	Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP) recorded from human induced pluripotent stem cell–derived cardiomyocytes.
In vitro	In isolated failing rabbit hearts with ischemia-reperfusion injury, Eleclazine (1 μM, 20 min perfusion) reduced APD dispersion and accelerated intracellular Ca²⁺ clearance, suppressing arrhythmogenic alternans. Under therapeutic hypothermia (33 °C, 30 min), Eleclazine further improved outcomes by reducing ventricular fibrillation (VF) inducibility and severity[1].
Alias	GS-6615, GS6615, Eleclazine free base

Chemical Properties

Molecular Weight	415.37
Formula	C₂₁H₁₆F₃N₃O₃
Cas No.	1443211-72-0
Smiles	O=C1C2=CC(=CC=C2OCCN1CC3=NC=CC=N3)C=4C=CC(OC(F)(F)F)=CC4

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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