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Anti-TIGIT Antibody (5L133)
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Catalog No. TMAY-01329
Alias Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552
Anti-TIGIT Antibody (5L133) is a Rabbit antibody targeting TIGIT. Anti-TIGIT Antibody (5L133) can be used in ELISA.
Anti-TIGIT Antibody (5L133)
Anti-TIGIT Antibody (5L133)
😃Good
Catalog No. TMAY-01329Alias Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552
Anti-TIGIT Antibody (5L133) is a Rabbit antibody targeting TIGIT. Anti-TIGIT Antibody (5L133) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Chemical Properties
| Description | Anti-TIGIT Antibody (5L133) is a Rabbit antibody targeting TIGIT. Anti-TIGIT Antibody (5L133) can be used in ELISA. |
| Alias | Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5L133 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TIGIT (rh TIGIT; NP_776160.2Met1-Phe138). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human TIGIT Protein |
| Antigen Species | Human |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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