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PLK1/BRD4-IN-5
🥰Excellent
Catalog No. T209444
PLK1/BRD4-IN-5 (Compound SC10) is an orally active inhibitor of PLK1 and BRD4, exhibiting IC50 values of 0.3 nM and 60.8 nM, respectively. It induces S phase cell cycle arrest and dose-dependent apoptosis in MV4-11 cells. PLK1/BRD4-IN-5 is useful for cancer research.
PLK1/BRD4-IN-5
PLK1/BRD4-IN-5
🥰Excellent
Catalog No. T209444
PLK1/BRD4-IN-5 (Compound SC10) is an orally active inhibitor of PLK1 and BRD4, exhibiting IC50 values of 0.3 nM and 60.8 nM, respectively. It induces S phase cell cycle arrest and dose-dependent apoptosis in MV4-11 cells. PLK1/BRD4-IN-5 is useful for cancer research.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PLK1/BRD4-IN-5 (Compound SC10) is an orally active inhibitor of PLK1 and BRD4, exhibiting IC50 values of 0.3 nM and 60.8 nM, respectively. It induces S phase cell cycle arrest and dose-dependent apoptosis in MV4-11 cells. PLK1/BRD4-IN-5 is useful for cancer research. |
| Targets&IC50 | PLK1:0.3 nM, BRD4:60.8 nM |
| In vitro | PLK1/BRD4-IN-5 (Compound SC10) exhibits significant antiproliferative activity against three tumor cell lines with IC50 values of 17.3 nM for MDA-MB-231, 8.4 nM for MDA-MB-361, and 5.4 nM for MV4-11. |
| Formula | C31H44N8O3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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