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ARQ 531

Name: ARQ 531
Brand: TargetMol
SKU: T14323
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14323Cas No. 2095393-15-8

ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

ARQ 531

🥰Excellent

Purity: 99.63%

Catalog No. T14323Cas No. 2095393-15-8

ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

Pack Size	Price	Availability
2 mg	$41	In Stock
5 mg	$89	In Stock
10 mg	$129	In Stock
25 mg	$222	In Stock
50 mg	$355	In Stock
100 mg	$567	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Purity:99.63%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.
Targets&IC50	BTK (C481S):0.39 nM, BTK (WT):0.85 nM
In vitro	In vitro treatment of patient CLL cells with ARQ 531 decreases BTK-mediated functions including B-cell receptor (BCR) signaling, viability, migration, CD40 and CD86 expression, and NF-κB gene transcription.?Additionally, ARQ 531 inhibits CLL cell survival and suppresses BCR-mediated activation of C481S BTK and PLCγ2 mutants, which facilitate clinical resistance to ibrutinib[2].
In vivo	In vivo, ARQ 531 was found to increase survival over ibrutinib in a murine Eμ-TCL1 engraftment model of CLL and a murine Eμ-MYC/TCL1 engraftment model resembling Richter transformation[2].

Chemical Properties

Molecular Weight	478.93
Formula	C₂₅H₂₃ClN₄O₄
Cas No.	2095393-15-8
Smiles	OC[C@@H]1CC[C@H](CO1)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (104.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0880 mL	10.4399 mL	20.8799 mL	104.3994 mL
5 mM	0.4176 mL	2.0880 mL	4.1760 mL	20.8799 mL
10 mM	0.2088 mL	1.0440 mL	2.0880 mL	10.4399 mL
20 mM	0.1044 mL	0.5220 mL	1.0440 mL	5.2200 mL
50 mM	0.0418 mL	0.2088 mL	0.4176 mL	2.0880 mL
100 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0440 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc