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2-Ketoglutaric acid Sodium

Name: 2-Ketoglutaric acid Sodium
Brand: TargetMol
SKU: T4920
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4920Cas No. 22202-68-2

Alias α-Ketoglutaric acid sodium salt, Oxoglutaric acid, AKG, 2-oxoglutarate monobasic

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

2-Ketoglutaric acid Sodium

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Purity: 97.77%

Catalog No. T4920Alias α-Ketoglutaric acid sodium salt, Oxoglutaric acid, AKG, 2-oxoglutarate monobasicCas No. 22202-68-2

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$44	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.77%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.
Targets&IC50	Tyrosinase:15 mM (IC50)
In vitro	2-Ketoglutaric acid Sodium is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. In particular, 2-Ketoglutaric acid Sodium can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in skeletal muscles. It has recently been shown that 2-Ketoglutaric acid Sodium can extend the lifespan of adult C. elegans by inhibiting ATP synthase and TOR. In combination with molecular oxygen, alpha-ketoglutarate is required for the hydroxylation of proline to hydroxyproline in the production of type I collagen. A recent study has shown that alpha-ketoglutarate promotes TH1 differentiation along with the depletion of glutamine thereby favouring Treg (regulatory T-cell) differentiation.
Synonyms	α-Ketoglutaric acid sodium salt, Oxoglutaric acid, AKG, 2-oxoglutarate monobasic

Chemical Properties

Molecular Weight	168.08
Formula	C₅H₅NaO₅
Cas No.	22202-68-2
Smiles	[Na+].OC(=O)CCC(=O)C([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (297.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9495 mL	29.7477 mL	59.4955 mL	297.4774 mL
5 mM	1.1899 mL	5.9495 mL	11.8991 mL	59.4955 mL
10 mM	0.5950 mL	2.9748 mL	5.9495 mL	29.7477 mL
20 mM	0.2975 mL	1.4874 mL	2.9748 mL	14.8739 mL
50 mM	0.1190 mL	0.5950 mL	1.1899 mL	5.9495 mL
100 mM	0.0595 mL	0.2975 mL	0.5950 mL	2.9748 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc