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XE991

Catalog No. T78570 CAS 122955-42-4

XE991 is a novel and selective Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current, and can be used for the study of neurological diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

XE991, CAS 122955-42-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 549.00
100 mg	In stock	$ 883.00
500 mg	In stock	$ 1,770.00
1 mL * 10 mM (in DMSO)	In stock	$ 107.00

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Purity: 99.51%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	XE991 is a novel and selective Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current, and can be used for the study of neurological diseases.
Targets&IC50	[3H] acetylcholine:490 nM
In vitro	XE991 and DMP 543 have EC50 values of 490 nM and 700 nM, respectively, for enhancing [3H] acetylcholine release from rat brain slices[2].

Molecular Weight	376.45
Formula	C26H20N2O
CAS No.	122955-42-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. 2. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

XE991 122955-42-4 Membrane transporter/Ion channel Potassium Channel inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.