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Lasofoxifene
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Catalog No. T62119Cas No. 180916-16-9
Alias CW-008, CW008
Lasofoxifene (CP-336156) is a selective oestrogen receptor modulator/antagonist that reduces serum IL-6 levels and inhibits joint inflammation and osteoporosis. It suppresses primary tumour growth and metastasis, making it suitable for breast cancer research.
Lasofoxifene
😃Good
Purity: 99.6%
Catalog No. T62119Alias CW-008, CW008Cas No. 180916-16-9
Lasofoxifene (CP-336156) is a selective oestrogen receptor modulator/antagonist that reduces serum IL-6 levels and inhibits joint inflammation and osteoporosis. It suppresses primary tumour growth and metastasis, making it suitable for breast cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $34 | - | In Stock | |
| 5 mg | $53 | - | In Stock | |
| 10 mg | Preferential | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.6%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lasofoxifene (CP-336156) is a selective oestrogen receptor modulator/antagonist that reduces serum IL-6 levels and inhibits joint inflammation and osteoporosis. It suppresses primary tumour growth and metastasis, making it suitable for breast cancer research. |
| In vivo | Methods: Lasofoxifene (1, 5, and 10 mg/kg, 5 times per week) was administered subcutaneously to NSG mice with established human-derived xenograft models (MIND models) to assess the antitumor activity of lasofoxifene in endocrine therapy-resistant ER+ breast cancer mouse models. Results: Lasofoxifene demonstrated superior efficacy in inhibiting tumor growth and metastasis compared to fulvestrant, especially in Y537S and D538G mutant tumors, where lasofoxifene showed stronger inhibitory effects. [1] |
| Synonyms | CW-008, CW008 |
| Molecular Weight | 413.55 |
| Formula | C28H31NO2 |
| Cas No. | 180916-16-9 |
| Smiles | OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6.5 mg/mL (15.72 mM), when pH is adjusted to 4 with 1M HCl. Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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