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Milatuzumab

Catalog No. T77478 CAS 899796-83-9

Synonyms: hLL1, MEDI-115

Milatuzumab (MEDI-115) is a humanized monoclonal antibody against CD74. Milatuzumab promotes the production of free radical oxygen and the loss of mitochondrial membrane potential, reduces CD20/CD74 aggregates and cell adhesion, and induces cell death.

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Milatuzumab

Milatuzumab, CAS 899796-83-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 753.00
10 mg	In stock	$ 1,180.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Milatuzumab (MEDI-115) is a humanized monoclonal antibody against CD74. Milatuzumab promotes the production of free radical oxygen and the loss of mitochondrial membrane potential, reduces CD20/CD74 aggregates and cell adhesion, and induces cell death.
In vitro	Milatuzumab (5 μg/mL; 8-48 hours) enhanced cell death in MCL cell lines and primary patient tumor cells[1]. In Jeko, Mino, and SP-53 cells, milatuzumab (5 μg/mL; 0.5-2 h) mediated cytotoxicity, depending in part on ROS production and loss of mitochondrial transmembrane potential[1]. Milatuzumab (5 μg/mL; 4 hours) inhibited the NF-κB pathway and induced apoptosis. The mechanism of apoptosis was not related to caspase cleavage, Bcl-2 family member disorder, or autophagy induction[1].
In vivo	Administered at a dose of 15 mg/kg/day via intraperitoneal injection every 3 days, milatuzumab significantly increased the survival rate of female SCID mice carrying Jeko cancer cells. Additionally, Milatuzumab and Rituximab demonstrated a synergistic effect in this mouse model[1].

Synonyms	hLL1, MEDI-115
Molecular Weight	N/A
CAS No.	899796-83-9

Storage

store at low temperature

store at -80°C

References and Literature

1. Alinari L, et al. Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma. Blood. 2011 Apr 28;117(17):4530-41.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Milatuzumab 899796-83-9 Others MEDI115 hLL1 MEDI-115 MEDI 115 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.