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U18666A

Name: U18666A
Brand: TargetMol
SKU: T17190
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17190Cas No. 3039-71-2

U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.

U18666A

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Purity: 99.79%

Catalog No. T17190Cas No. 3039-71-2

U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$29	In Stock	In Stock
2 mg	$37	In Stock	In Stock
5 mg	$61	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$185	In Stock	In Stock
50 mg	$301	In Stock	In Stock
100 mg	$453	In Stock	In Stock
200 mg	$651	-	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.
In vitro	U18666A exhibits antiviral effects by impeding viral trafficking within cholesterol-laden late endosomes/lysosomes and inhibiting de novo sterol biosynthesis in infected cells. Additionally, an additive antiviral effect is observed when U18666A is combined with C75, a fatty acid synthase inhibitor [1][2].

Chemical Properties

Molecular Weight	424.06
Formula	C₂₅H₄₂ClNO₂
Cas No.	3039-71-2
Smiles	Cl.[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OCCN(CC)CC
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (117.91 mM), Sonication is recommended.

H2O: 10 mg/mL (23.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3582 mL	11.7908 mL	23.5816 mL	117.9078 mL
5 mM	0.4716 mL	2.3582 mL	4.7163 mL	23.5816 mL
10 mM	0.2358 mL	1.1791 mL	2.3582 mL	11.7908 mL
20 mM	0.1179 mL	0.5895 mL	1.1791 mL	5.8954 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0472 mL	0.2358 mL	0.4716 mL	2.3582 mL
100 mM	0.0236 mL	0.1179 mL	0.2358 mL	1.1791 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc