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Anti-OAT-1 Polyclonal Antibody
(Synonyms: solute carrier family 22(organic anion transporter), member 6, SLC22A6, S22A6, ROAT1, PAHT, Organic anion transporter 1, Orctl1, OAT1, Oat, NKT, mOat1, MGC45260, MGC124962, HOAT1, FLJ55736) Copy Product Info
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Synonyms: solute carrier family 22(organic anion transporter), member 6, SLC22A6, S22A6, ROAT1, PAHT, Organic anion transporter 1, Orctl1, OAT1, Oat, NKT, mOat1, MGC45260, MGC124962, HOAT1, FLJ55736
Catalog No. TMAB-01278 Copy Product Info
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Anti-OAT-1 Polyclonal Antibody is a Rabbit antibody targeting CYP11A1. Anti-OAT-1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-OAT-1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-OAT-1 Polyclonal Antibody is a Rabbit antibody targeting CYP11A1. Anti-OAT-1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | solute carrier family 22(organic anion transporter), member 6, SLC22A6, S22A6, ROAT1, PAHT, Organic anion transporter 1, Orctl1, OAT1, Oat, NKT, mOat1, MGC45260, MGC124962, HOAT1, FLJ55736 |
| Ig Type | IgG |
| Reactivity | Human,Mouse(predicted:Rat) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC. These families play critical roles in the transepithelial transport of organic anions in the kidneys as well as in other tissues such as the liver and brain. Among these families, the OAT family plays the central role in renal organic anion transport. Knowledge of these three families at the molecular level, such as substrate selectivity, tissue distribution, and gene localization, is rapidly increasing. |
| Immunogen | KLH conjugated synthetic peptide: human OCT-1 |
| Antigen Species | Human |
| Gene Name | SLC22A6 |
| Gene ID | |
| Protein Name | Solute carrier family 22 member 6 |
| Uniprot ID | |
| Biology Area | Channels |
| Function | Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. |
| Molecular Weight | Theoretical: 62 kDa. Actual: 62 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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