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Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2

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Catalog No. TMAC-03356

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF2AK2 (Thr446). Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody can be used in WB,IP,IF,IHC.

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2

😃Good
Catalog No. TMAC-03356
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF2AK2 (Thr446). Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody can be used in WB,IP,IF,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF2AK2 (Thr446). Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody can be used in WB,IP,IF,IHC.
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:100-1000; IHC: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationImmunogen affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundAn interferon-inducible, RNA-dependent protein serine/threonine kinase, PKR has various designations. Mouse PKR is known as DAI, dsJ, PI kinase, p65, p67 or TIK, whereas human PKR is known as p68 or p69. PKR phosphorylates its substrate, a subunit of protein synthesis initiation factor eIF-2 on Ser 51 to inhibit translation. PKR contains two dsRNA binding motifs required for its activation by dsRNA. Three kinds of regulation of PKR enzymatic activity occur, and these include transcriptional regulation in response to interferon, an autoregulatory mechanism controlling PKR expression at the level of translation, and posttranslational regulation by RNA mediated autophosphorylation. Human PKR contains at least 15 autophosphorylation sites, but only Thr-446 and Thr-451 in the activation loop are critical for its kinase activity. Thr-446 is the in vivo autophosphorylation site of PKR. Mutation of threonine to alanine at position 446 substantially reduces PKR function, and mutant kinase containing Ala-451 is completely inactive.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Amino acid sequence containing phosphorylated Thr 446 of PKR of human origin
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 68 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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