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Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2
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Catalog No. TMAC-03356
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF2AK2 (Thr446). Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody can be used in WB,IP,IF,IHC.
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2
😃Good
Catalog No. TMAC-03356
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF2AK2 (Thr446). Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody can be used in WB,IP,IF,IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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| Description | Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF2AK2 (Thr446). Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody can be used in WB,IP,IF,IHC. |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:100-1000; IHC: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Immunogen affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | An interferon-inducible, RNA-dependent protein serine/threonine kinase, PKR has various designations. Mouse PKR is known as DAI, dsJ, PI kinase, p65, p67 or TIK, whereas human PKR is known as p68 or p69. PKR phosphorylates its substrate, a subunit of protein synthesis initiation factor eIF-2 on Ser 51 to inhibit translation. PKR contains two dsRNA binding motifs required for its activation by dsRNA. Three kinds of regulation of PKR enzymatic activity occur, and these include transcriptional regulation in response to interferon, an autoregulatory mechanism controlling PKR expression at the level of translation, and posttranslational regulation by RNA mediated autophosphorylation. Human PKR contains at least 15 autophosphorylation sites, but only Thr-446 and Thr-451 in the activation loop are critical for its kinase activity. Thr-446 is the in vivo autophosphorylation site of PKR. Mutation of threonine to alanine at position 446 substantially reduces PKR function, and mutant kinase containing Ala-451 is completely inactive. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Amino acid sequence containing phosphorylated Thr 446 of PKR of human origin |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 68 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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