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PROTAC KRAS G12C degrader-2
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Catalog No. T87266Cas No. 2378257-72-6
PROTAC KRAS G12C degrader-2 (compound 432) is a targeted modulator of K-Ras protein hydrolysis that functions as a bifunctional PROTAC molecule, incorporating a cereblon inhibitor of apoptosis proteins (IAP) ligand on one terminus and a KRAS-binding moiety on the opposite end, thereby enabling selective recruitment of mutant KRAS G12C to the ubiquitin–proteasome system for controlled degradation and mechanistic investigation of KRAS-driven oncogenic signaling pathways.
PROTAC KRAS G12C degrader-2
😃Good
Catalog No. T87266Cas No. 2378257-72-6
PROTAC KRAS G12C degrader-2 (compound 432) is a targeted modulator of K-Ras protein hydrolysis that functions as a bifunctional PROTAC molecule, incorporating a cereblon inhibitor of apoptosis proteins (IAP) ligand on one terminus and a KRAS-binding moiety on the opposite end, thereby enabling selective recruitment of mutant KRAS G12C to the ubiquitin–proteasome system for controlled degradation and mechanistic investigation of KRAS-driven oncogenic signaling pathways.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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| Description | PROTAC KRAS G12C degrader-2 (compound 432) is a targeted modulator of K-Ras protein hydrolysis that functions as a bifunctional PROTAC molecule, incorporating a cereblon inhibitor of apoptosis proteins (IAP) ligand on one terminus and a KRAS-binding moiety on the opposite end, thereby enabling selective recruitment of mutant KRAS G12C to the ubiquitin–proteasome system for controlled degradation and mechanistic investigation of KRAS-driven oncogenic signaling pathways. |
| Molecular Weight | 958.47 |
| Formula | C51H53ClFN9O7 |
| Cas No. | 2378257-72-6 |
| Smiles | FC=1C2=C(C(=NC(O[C@@H](CN3CCN(CC4CCN(CC4)C=5C=C6C(=CC5)C(=O)N(C6=O)C7C(=O)NC(=O)CC7)CC3)C)=N2)N8CCN(C(C=C)=O)CC8)C=C(Cl)C1C=9C%10=C(C=C(O)C9)C=CC=C%10 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (41.73 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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