MIV-150

Name: MIV-150
Brand: TargetMol
SKU: T16081
Rating: 4.5 (1 reviews)

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Catalog No. T16081Cas No. 231957-54-3

Alias PC 815

MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).

MIV-150

😃Good

Catalog No. T16081Alias PC 815Cas No. 231957-54-3

MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$398	35 days	35 days
1 mg	$693	35 days	35 days
5 mg	$2,730	35 days	35 days
10 mg	$3,880	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).
Targets&IC50	HIV-1:<1 nM (EC50), HIV-2:<1 nM (EC50)
In vitro	MIV-150 demonstrates potent antiviral efficacy by inactivating free HIV virus with an EC50 of 0.004 μg/mL (or 0.01 μM), showcasing its high effectiveness against HIV, including strains resistant to other marketed antiretrovirals like Nevirapine, Delavirdine, and Efavirenz. Remarkably, resistance to MIV-150 develops slower compared to other anti-HIV drugs, as evident from in vitro studies where resistance to Nevirapine and Delavirdine emerged within 4 to 5 weeks, whereas resistance to MIV-150 took up to 45 weeks. Additionally, MIV-150's ability to protect target cells from infection was demonstrated through a syncytial assay, revealing an EC50 against HIV-1MN in CEM.SS cells below 1 nM, aligning with Medivir's findings.
Synonyms	PC 815

Chemical Properties

Molecular Weight	368.36
Formula	C₁₉H₁₇FN₄O₃
Cas No.	231957-54-3
Smiles	N(C(NC1=CC=C(C#N)C=N1)=O)[C@@H]2[C@@H](C2)C3=C(O)C(C(CC)=O)=CC=C3F
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc