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Anti-Cleaved PARP1 p25 Antibody (6E10)
😃Good
Catalog No. TMAB-04444
Anti-Cleaved PARP1 p25 Antibody (6E10) is a Rabbit antibody targeting Cleaved PARP1 p25. Anti-Cleaved PARP1 p25 Antibody (6E10) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF,IP.
Anti-Cleaved PARP1 p25 Antibody (6E10)
Anti-Cleaved PARP1 p25 Antibody (6E10)
😃Good
Catalog No. TMAB-04444
Anti-Cleaved PARP1 p25 Antibody (6E10) is a Rabbit antibody targeting Cleaved PARP1 p25. Anti-Cleaved PARP1 p25 Antibody (6E10) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF,IP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Cleaved PARP1 p25 Antibody (6E10) is a Rabbit antibody targeting Cleaved PARP1 p25. Anti-Cleaved PARP1 p25 Antibody (6E10) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF,IP. |
| Ig Type | IgG |
| Clone | 6E10 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1:50-200; ICC/IF: 1:50-200; IP: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human PARP1 |
| Antigen Species | Human |
| Gene Name | PARP1 |
| Gene ID | |
| Protein Name | Poly [ADP-ribose] polymerase 1 |
| Uniprot ID | |
| Function | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. |
| Molecular Weight | Theoretical: 25/114 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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