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Anti-Phospho-cdc2 (Tyr15) Antibody (2T187)
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Catalog No. TMAY-01670
Alias P34CDC2, CDKN1, CDC28A, CDC2, CDC 2
Anti-Phospho-cdc2 (Tyr15) Antibody (2T187) is a Rabbit antibody targeting Phospho-cdc2 (Tyr15). Anti-Phospho-cdc2 (Tyr15) Antibody (2T187) can be used in WB.
Anti-Phospho-cdc2 (Tyr15) Antibody (2T187)
Anti-Phospho-cdc2 (Tyr15) Antibody (2T187)
😃Good
Catalog No. TMAY-01670Alias P34CDC2, CDKN1, CDC28A, CDC2, CDC 2
Anti-Phospho-cdc2 (Tyr15) Antibody (2T187) is a Rabbit antibody targeting Phospho-cdc2 (Tyr15). Anti-Phospho-cdc2 (Tyr15) Antibody (2T187) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $81 | 7-10 days | |
| 100 μL | $233 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-cdc2 (Tyr15) Antibody (2T187) is a Rabbit antibody targeting Phospho-cdc2 (Tyr15). Anti-Phospho-cdc2 (Tyr15) Antibody (2T187) can be used in WB. |
| Alias | P34CDC2, CDKN1, CDC28A, CDC2, CDC 2 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 2T187 |
| Reactivity | Human;
Species predicted to react based on 100% sequence homology: Mouse, Rat, Cynomolgus, Bovin, Chick |
| Verified Activity | 1. Western blot analysis of extracts from serum-starved Hela, untreated (-) or treated with hydroxyurea (4mm, 24h; +), using Phospho-Cdc2 (Tyr15) Antibody, Rabbit MAb at 1:10000 dilution (upper) or Anti-CDK1/CDC2 Antibody, Rabbit PAb at 1:2000 dilution (lower). 2. Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with hydroxyurea (4mm, 24h, +) (line B); treated with hydroxyurea and λ-phosphatase (line C) using Phospho-Cdc2 (Tyr15) Antibody, Rabbit MAb at 1:10000 dilution. |
| Application | WB |
| Recommended Dose | WB: 1:5000-1:50000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Tyr15 of the Human cdc2. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Research Background | CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. The kinase activity of CDK1 is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of CDC2 also play important regulatory roles in cell cycle control. It is required in higher cells for entry into S-phase and mitosis. CDC2 also is a cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. It has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. CDK1 is required for RNA splicing, possibly by phosphorylating SRSF1/SF2. It is involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic phosphopeptide corresponding to residues around Tyr15 of the Human cdc2 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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