Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 447.00 | |
25 mg | In stock | $ 647.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,330.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 317.00 |
Description | GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1]. |
In vitro | GA-017 suppresses the HUVECs cell death and promotes their cell growth [1]. GA-017 facilitates SKOV3 cell growth, with an EC 50 of 3.51 ± 0.26 μM [1]. GA-017 competitively inhibited LATS1 and 2 against ATP, with K i (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively [1]. |
Molecular Weight | 343.38 |
Formula | C18H21N3O4 |
CAS No. | 2351906-74-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 18.9 mg/mL (55 mM), Sonication and heating to 80℃ are recommended.
You can also refer to dose conversion for different animals. More
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GA-017 2351906-74-4 Others GA017 GA 017 inhibitor inhibit