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N-Acetylputrescine (Synonyms: NAP)

Name: N-Acetylputrescine
Brand: TargetMol
SKU: T77257
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T77257 Copy Product Info

Purity: 99.94%

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N-Acetylputrescine is an acetylated metabolite of the polyamine putrescine. N-Acetylputrescine participates in polyamine metabolism and regulatory processes within cells and reflects the dynamic balance between polyamine synthesis and degradation. N-Acetylputrescine exhibits activity toward the peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) (Ki = 800 μM) and is commonly used as a metabolic biomarker to study polyamine metabolic changes in cellular proliferation, gut microbiota metabolism, and related disease states.

N-Acetylputrescine

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Catalog No. T77257

Synonyms NAP

Cas No. 5699-41-2

Pack Size	Price	USA Stock	Global Stock
200 mg	$31	-	In Stock
500 mg	$48	-	In Stock
1 g	$68	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

Appearance:Liquid

Color:Transparent

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	N-Acetylputrescine is an acetylated metabolite of the polyamine putrescine. N-Acetylputrescine participates in polyamine metabolism and regulatory processes within cells and reflects the dynamic balance between polyamine synthesis and degradation. N-Acetylputrescine exhibits activity toward the peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) (Ki = 800 μM) and is commonly used as a metabolic biomarker to study polyamine metabolic changes in cellular proliferation, gut microbiota metabolism, and related disease states.
In vitro	N-Acetylputrescine (radioactive label; 72 h) is synthesized by putrescine in human lymphocyte culture, which can be released into the culture medium. Its production is related to the cell proliferation state and may participate in the regulation of polyamine metabolism [2].
In vivo	The concentration of N-Acetylputrescine in rat lung squamous cell carcinoma (SCCL) model induced by 3-methylcholanthrene increased significantly with the progress of cancer, and after being treated with anticancer agents, the concentration of N-Acetylputrescine decreased, which can be used as a potential biomarker for early diagnosis and evaluation of SCC [3].
Synonyms	NAP

Chemical Properties

Molecular Weight	130.19
Formula	C₆H₁₄N₂O
Cas No.	5699-41-2
Smiles	O=C(NCCCCN)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100.00 mg/mL (768.11 mM), Sonication is recommended.

DMSO: 100.00 mg/mL (768.11 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.6811 mL	38.4054 mL	76.8108 mL	384.0541 mL
5 mM	1.5362 mL	7.6811 mL	15.3622 mL	76.8108 mL
10 mM	0.7681 mL	3.8405 mL	7.6811 mL	38.4054 mL
20 mM	0.3841 mL	1.9203 mL	3.8405 mL	19.2027 mL
50 mM	0.1536 mL	0.7681 mL	1.5362 mL	7.6811 mL
100 mM	0.0768 mL	0.3841 mL	0.7681 mL	3.8405 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc