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TY-51469

Name: TY-51469
Brand: TargetMol
SKU: T17186
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17186Cas No. 603987-59-3

TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).

TY-51469

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Purity: 99.65%

Catalog No. T17186Cas No. 603987-59-3

TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$60	In Stock	In Stock
10 mg	$108	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$793	-	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.65%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).
Targets&IC50	Simian chymase:0.4 nM, Chymase (human):0.7 nM
In vivo	TY-51469 inhibits the accumulation of neutrophils in the lung and decreases silica-induced pulmonary fibrosis in mice. TY-51469 displays 100% stability in rat plasma at 40°C for as long as 1 hour [1].

Chemical Properties

Molecular Weight	526.6
Formula	C₂₀H₁₅FN₂O₆S₄
Cas No.	603987-59-3
Smiles	Cc1c(sc2ccc(F)cc12)S(=O)(=O)Nc1ccc(cc1S(C)(=O)=O)-c1nc(cs1)C(O)=O
Relative Density.	1.620 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (85.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8990 mL	9.4949 mL	18.9897 mL	94.9487 mL
5 mM	0.3798 mL	1.8990 mL	3.7979 mL	18.9897 mL
10 mM	0.1899 mL	0.9495 mL	1.8990 mL	9.4949 mL
20 mM	0.0949 mL	0.4747 mL	0.9495 mL	4.7474 mL
50 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc