Shopping Cart

Remove All
Your shopping cart is currently empty

TY-51469

Name: TY-51469
Brand: TargetMol
SKU: T17186
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17186Cas No. 603987-59-3

TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).

TY-51469

🥰Excellent

Purity: 99.65%

Catalog No. T17186Cas No. 603987-59-3

TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$116	In Stock
25 mg	$277	In Stock
50 mg	$486	In Stock
100 mg	$852	In Stock
200 mg	$1,145	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.65%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).
Targets&IC50	Chymase (human):0.7 nM, Simian chymase:0.4 nM
In vivo	TY-51469 inhibits the accumulation of neutrophils in the lung and decreases silica-induced pulmonary fibrosis in mice. TY-51469 displays 100% stability in rat plasma at 40°C for as long as 1 hour [1].

Chemical Properties

Molecular Weight	526.6
Formula	C₂₀H₁₅FN₂O₆S₄
Cas No.	603987-59-3
Smiles	Cc1c(sc2ccc(F)cc12)S(=O)(=O)Nc1ccc(cc1S(C)(=O)=O)-c1nc(cs1)C(O)=O
Relative Density.	1.620 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (85.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8990 mL	9.4949 mL	18.9897 mL	94.9487 mL
5 mM	0.3798 mL	1.8990 mL	3.7979 mL	18.9897 mL
10 mM	0.1899 mL	0.9495 mL	1.8990 mL	9.4949 mL
20 mM	0.0949 mL	0.4747 mL	0.9495 mL	4.7474 mL
50 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8990 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc