keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This compound preferentially boosts intracellular calcium in Sf9 cells expressing the LPA2 receptor (EC50 = ~10 nM), compared to those with LPA1 and LPA3 receptors (EC50s = ~200 and ~80 nM, respectively). Notably, 1-linoleoyl LPA serum concentrations are elevated in mice with NCTC clone 2472 tumors, while its plasma levels are reduced in primary progressive multiple sclerosis patients—unlike in those with relapsing-remitting multiple sclerosis—and inversely associate with the severity of neurological deficits.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 168.00 | |
1 mg | 35 days | $ 294.00 |
Description | 1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This compound preferentially boosts intracellular calcium in Sf9 cells expressing the LPA2 receptor (EC50 = ~10 nM), compared to those with LPA1 and LPA3 receptors (EC50s = ~200 and ~80 nM, respectively). Notably, 1-linoleoyl LPA serum concentrations are elevated in mice with NCTC clone 2472 tumors, while its plasma levels are reduced in primary progressive multiple sclerosis patients—unlike in those with relapsing-remitting multiple sclerosis—and inversely associate with the severity of neurological deficits. |
Synonyms | 1-Linoleoyl-2-hydroxy-sn-glycero-3-PA, LPA(18:2), PA(18:2(9Z,12Z)/0:0), 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate, 18:2 Lyso PA, 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA, PA(18:2/0:0), 1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Linoleoyl LPA |
Molecular Weight | 434.50 |
Formula | C21H39O7P.XNa |
CAS No. | 72777-86-7 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: Soluble
Ethanol: Soluble
You can also refer to dose conversion for different animals. More
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1-Linoleoyl Lysophosphatidic Acid sodium 72777-86-7 1-Linoleoyl-2-hydroxy-sn-glycero-3-PA LPA(18:2) PA(18:2(9Z,12Z)/0:0) 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate 18:2 Lyso PA 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA PA(18:2/0:0) 1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate 1-Linoleoyl LPA inhibitor inhibit