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1-Linoleoyl Lysophosphatidic Acid sodium
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Catalog No. T83772Cas No. 72777-86-7
Alias PA(18:2/0:0), PA(18:2(9Z,12Z)/0:0), LPA(18:2), 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA, 1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Linoleoyl-2-hydroxy-sn-glycero-3-PA, 1-Linoleoyl LPA, 18:2 Lyso PA
1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This compound preferentially boosts intracellular calcium in Sf9 cells expressing the LPA2 receptor (EC50 = ~10 nM), compared to those with LPA1 and LPA3 receptors (EC50s = ~200 and ~80 nM, respectively). Notably, 1-linoleoyl LPA serum concentrations are elevated in mice with NCTC clone 2472 tumors, while its plasma levels are reduced in primary progressive multiple sclerosis patients—unlike in those with relapsing-remitting multiple sclerosis—and inversely associate with the severity of neurological deficits.
1-Linoleoyl Lysophosphatidic Acid sodium
😃Good
Catalog No. T83772Alias PA(18:2/0:0), PA(18:2(9Z,12Z)/0:0), LPA(18:2), 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA, 1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Linoleoyl-2-hydroxy-sn-glycero-3-PA, 1-Linoleoyl LPA, 18:2 Lyso PACas No. 72777-86-7
1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This compound preferentially boosts intracellular calcium in Sf9 cells expressing the LPA2 receptor (EC50 = ~10 nM), compared to those with LPA1 and LPA3 receptors (EC50s = ~200 and ~80 nM, respectively). Notably, 1-linoleoyl LPA serum concentrations are elevated in mice with NCTC clone 2472 tumors, while its plasma levels are reduced in primary progressive multiple sclerosis patients—unlike in those with relapsing-remitting multiple sclerosis—and inversely associate with the severity of neurological deficits.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 μg | $388 | 35 days | 35 days | |
| 1 mg | $578 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Storage & Solubility Information
| Description | 1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This compound preferentially boosts intracellular calcium in Sf9 cells expressing the LPA2 receptor (EC50 = ~10 nM), compared to those with LPA1 and LPA3 receptors (EC50s = ~200 and ~80 nM, respectively). Notably, 1-linoleoyl LPA serum concentrations are elevated in mice with NCTC clone 2472 tumors, while its plasma levels are reduced in primary progressive multiple sclerosis patients—unlike in those with relapsing-remitting multiple sclerosis—and inversely associate with the severity of neurological deficits. |
| Synonyms | PA(18:2/0:0), PA(18:2(9Z,12Z)/0:0), LPA(18:2), 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA, 1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Linoleoyl-2-hydroxy-sn-glycero-3-PA, 1-Linoleoyl LPA, 18:2 Lyso PA |
| Molecular Weight | 434.50 |
| Formula | C21H39O7P.XNa |
| Cas No. | 72777-86-7 |
| Smiles | O=C(CCCCCCC/C=C\C/C=C\CCCCC)OC[C@@H](O)COP(O)(O)=O.[Na] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Methanol: Soluble Ethanol: Soluble |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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