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Anti-C17ORF53 Monoclonal Antibody (5P621)
(Synonyms: Uncharacterized protein C17orf53, MGC3130, Hypothetical protein LOC78995, FLJ11594, CQ053_HUMAN, Chromosome 17 open reading frame 53, C17orf53) Copy Product Info
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Synonyms: Uncharacterized protein C17orf53, MGC3130, Hypothetical protein LOC78995, FLJ11594, CQ053_HUMAN, Chromosome 17 open reading frame 53, C17orf53
Catalog No. TMAC-00502 Copy Product Info
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Anti-C17ORF53 Monoclonal Antibody (5P621) is a Mouse antibody targeting C17ORF53. Anti-C17ORF53 Monoclonal Antibody (5P621) can be used in IF,FCM.
Anti-C17ORF53 Monoclonal Antibody
(5P621)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $298 | 7-10 days | 7-10 days | |
| 100 µL | $428 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-C17ORF53 Monoclonal Antibody (5P621) is a Mouse antibody targeting C17ORF53. Anti-C17ORF53 Monoclonal Antibody (5P621) can be used in IF,FCM. |
| Synonyms | Uncharacterized protein C17orf53, MGC3130, Hypothetical protein LOC78995, FLJ11594, CQ053_HUMAN, Chromosome 17 open reading frame 53, C17orf53 |
| Ig Type | IgG2b |
| Clone | 5P621 |
| Reactivity | Human |
| Verified Activity | 1. ICC staining C17ORF53 (green) in HepG2 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 2. Flow cytometric analysis of Jurkat cells with C17ORF53 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).  , |
| Application | |
| Recommended Dose | IF: 1/50-1/200; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | HROB |
| Gene ID | |
| Protein Name | Homologous recombination OB-fold protein |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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