PROC (protein C gene) is a 62-kDa vitamin K-dependent plasma zymogen which, after activation to serine protease, plays an important role in the physiologic regulation of blood coagulation. Originally thought to be synthesized exclusively by the liver, recent reports have shown that PROC is also produced by many other cells including pancreatic islet β cells. Protein C a vitamin K-dependent plasma glycoprotein and is one of the body’s natural anticoagulants circulating at 70 nmol/L as an inactive protease zymogen.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 μg | 5 days | $ 357.00 |
Description | PROC (protein C gene) is a 62-kDa vitamin K-dependent plasma zymogen which, after activation to serine protease, plays an important role in the physiologic regulation of blood coagulation. Originally thought to be synthesized exclusively by the liver, recent reports have shown that PROC is also produced by many other cells including pancreatic islet β cells. Protein C a vitamin K-dependent plasma glycoprotein and is one of the body’s natural anticoagulants circulating at 70 nmol/L as an inactive protease zymogen. |
Species | Human |
Expression System | HEK293 |
Tag | His |
Accession Number | P04070 |
Synonyms | PROC, APC, THPH4, protein C, inactivator of coagulation factors Va and VIIIa, PC, PROC1, THPH3 |
Construction | A DNA sequence encoding the human PROC (P04070) (Met1-Pro461) was expressed with a C-terminal polyhistidine tag. |
Protein Purity | > 95 % as determined by SDS-PAGE |
Molecular Weight | 51.5 kDa (predicted) |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | PROC (protein C gene) is a 62-kDa vitamin K-dependent plasma zymogen which, after activation to serine protease, plays an important role in the physiologic regulation of blood coagulation. Originally thought to be synthesized exclusively by the liver, recent reports have shown that PROC is also produced by many other cells including pancreatic islet β cells. Protein C a vitamin K-dependent plasma glycoprotein and is one of the body’s natural anticoagulants circulating at 70 nmol/L as an inactive protease zymogen. |
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Please read the User Guide of Recombinant Proteins for more specific information.
Protein C Protein, Human, Recombinant (His) THPH-3 PROC THPH 4 THPH 3 APC PROC 1 THPH4 THPH-4 PROC-1 protein C, inactivator of coagulation factors Va and VIIIa PC PROC1 THPH3 recombinant recombinant-proteins proteins protein