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Cefazolin

Name: Cefazolin
Brand: TargetMol
SKU: T8390
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8390Cas No. 25953-19-9

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Cefazolin

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Purity: 99.51%

Catalog No. T8390Cas No. 25953-19-9

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$48	In Stock	In Stock
500 mg	$107	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.51%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Cefazolin AI Summary

Cefazolin exhibits a broad spectrum of bioactivities, including significant antimicrobial activity against a variety of bacterial strains. Its antibacterial efficacy varies widely depending on the strain and resistance profile, with notable activity against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, among others. The minimum inhibitory concentrations (MIC) for Cefazolin span from sub-microgram to high micromolar levels, indicating diverse potency across different bacterial targets. Additionally, Cefazolin demonstrates dynamic hydrolysis rates under different pH conditions, with a higher rate of hydrolysis at more alkaline pH values, specifically pH 10 compared to pH 9.6. The compound also shows low binding affinity to the membrane transport protein PEPT1 in human Caco-2 cells and exhibits antiproliferative effects in various human cell lines, including primary human osteoblasts, MG63 cells, and HeLa cells. In terms of pharmacokinetic properties, Cefazolin has a high oral bioavailability of 90% and favorable pharmacokinetics such as a volume of distribution at steady state of 0.1 L.kg-1, and a total body clearance of 0.89 mL.min-1.kg-1, indicating efficient absorption and moderate elimination from the body. The compound also shows significant protein binding in plasma and some degree of renal clearance. Cefazolin has been observed to exhibit moderate liver toxicity during clinical trials, marked by elevated serum enzyme levels. It shows a broad range of activity in various bioassays, including those for transporter inhibition, bacterial efflux pump interactions, and activity against specific metabolic pathways and enzymes in pathogenic organisms. The compound also displays potential antiviral properties, including inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells, albeit at high concentrations. Overall, Cefazolin is characterized by extensive antimicrobial efficacy, dynamic pH-dependent hydrolysis, significant pharmacokinetic attributes, and potential antiviral effects, rendering it a compound of interest for further research and development in antimicrobial and antiviral therapeutics..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Chemical Properties

Molecular Weight	454.51
Formula	C₁₄H₁₄N₈O₄S₃
Cas No.	25953-19-9
Smiles	[H][C@]12SCC(CSc3nnc(C)s3)=C(N1C(=O)[C@H]2NC(=O)Cn1cnnn1)C(O)=O
Relative Density.	2.01g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (550.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2002 mL	11.0009 mL	22.0017 mL	110.0086 mL
5 mM	0.4400 mL	2.2002 mL	4.4003 mL	22.0017 mL
10 mM	0.2200 mL	1.1001 mL	2.2002 mL	11.0009 mL
20 mM	0.1100 mL	0.5500 mL	1.1001 mL	5.5004 mL
50 mM	0.0440 mL	0.2200 mL	0.4400 mL	2.2002 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.1001 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc