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Zidebactam

Name: Zidebactam
Brand: TargetMol
SKU: T13395L
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: WCK-5107) Copy Product Info

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Synonyms: WCK-5107

Catalog No. T13395L Copy Product Info

Purity: 99.69%

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Zidebactam (WCK-5107) is a β-lactamase inhibitor and a penicillin-binding protein 2 (PBP2) inhibitor (IC50 = 0.26 μg/ml), with enzymatic inhibitory activity, and can be used for antibacterial research.

Cas No. 1436861-97-0

Pack Size	Price	USA Stock	Global Stock
1 mg	$88	In Stock	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$533	In Stock	In Stock
50 mg	$768	In Stock	In Stock
100 mg	$1,080	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.69%

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Zidebactam (WCK-5107) is a β-lactamase inhibitor and a penicillin-binding protein 2 (PBP2) inhibitor (IC50 = 0.26 μg/ml), with enzymatic inhibitory activity, and can be used for antibacterial research.
Targets & IC50	Enterobacter spp:0.12 mg/L (MIC50), PBP2:0.26 μg/ml (P. aeruginosa PAO1 PBP2), E. coli:0.12 mg/L (MIC50), Enterobacteriaceae (WT):0.25 mg/L (MIC50)
In vitro	Methods:Acinetobacter baumannii ATCC 19606 and OXA-23-producing clinical ST2 isolates were used to evaluate Zidebactam in vitro activity through MIC determination, PBP binding affinity determination (IC₅₀), and time-kill kinetics assays. Results: Zidebactam monotherapy showed MIC >1024 μg/mL, but exhibited high affinity for PBP2 (IC₅₀ 0.01 μg/mL); when combined with 8 μg/mL cefepime or sulbactam, MIC decreased by 4-8 fold, with complete bacterial clearance achieved within 24 hours.[1] Methods: Ninety-three carbapenemase-producing Klebsiella species and other isolates were used to determine the minimum inhibitory concentration (MIC) of Zidebactam alone and in combination with cefepime or ertapenem (1:1) by BSAC agar dilution method, with inoculum ranging from 3-6×10³ to 3-6×10⁵ CFU/spot. Results: For metallo-β-lactamase-producing strains, the MIC of Zidebactam combinations increased significantly (≥32-fold) with increasing inoculum, while the effect on non-MBL-producing strains was minimal.[2]
In vivo	Methods: A neutropenic mouse pneumonia model was established by intranasal inoculation with Pseudomonas aeruginosa. Zidebactam was administered subcutaneously at doses simulating human alveolar epithelial lining fluid exposure (3.8, 4.15 mg/kg) every 8 hours for 24 hours, with normal saline as the vehicle. Results: Zidebactam monotherapy reduced bacterial load by 0.99 log₁₀ CFU/lung, while combination with cefepime (WCK 5222) increased the reduction to 2.21 log₁₀ CFU/lung, demonstrating synergistic enhancement.[3] Methods: A neutropenic mouse pneumonia model was established by intranasal inoculation with Acinetobacter baumannii. Zidebactam was administered subcutaneously at doses of 12.5 and 37.5 mg/kg every 2 hours for 24 hours, with normal saline as the vehicle. Results: Zidebactam monotherapy was ineffective, but when combined with cefepime, it reduced the percentage of time that free drug concentrations exceeded the MIC required for 1-log₁₀ bactericidal activity from 38.9% to 15.5%.[4]
Synonyms	WCK-5107

Chemical Properties

Molecular Weight	391.4
Formula	C₁₃H₂₁N₅O₇S
Cas No.	1436861-97-0
Smiles	OS(=O)(=O)ON1[C@H]2CN([C@@H](CC2)C(=O)NNC(=O)[C@@H]2CCCNC2)C1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (638.73 mM), Sonication is recommended.

H2O: 50 mg/mL (127.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5549 mL	12.7747 mL	25.5493 mL	127.7466 mL
5 mM	0.5110 mL	2.5549 mL	5.1099 mL	25.5493 mL
10 mM	0.2555 mL	1.2775 mL	2.5549 mL	12.7747 mL
20 mM	0.1277 mL	0.6387 mL	1.2775 mL	6.3873 mL
50 mM	0.0511 mL	0.2555 mL	0.5110 mL	2.5549 mL
100 mM	0.0255 mL	0.1277 mL	0.2555 mL	1.2775 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.