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THZ1-R

Name: THZ1-R
Brand: TargetMol
SKU: T13153
Rating: 4.5 (1 reviews)

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Catalog No. T13153Cas No. 1621523-07-6

Alias THZ1R

THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, losing its ability to covalently bind to the C312 cysteine residue of CDK7. Its CDK7 inhibitory activity is weaker than that of THZ1.

THZ1-R

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Catalog No. T13153Alias THZ1RCas No. 1621523-07-6

Pack Size	Price	Availability
2 mg	$346	6-8 weeks
5 mg	$497	In Stock
25 mg	$1,543	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks
1 mL x 10 mM (in DMSO)	$547	6-8 weeks

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Product Introduction

Bioactivity

Description	THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, losing its ability to covalently bind to the C312 cysteine residue of CDK7. Its CDK7 inhibitory activity is weaker than that of THZ1.
Targets&IC50	CDK7:146 nM
In vitro	Method: Loucy cells were treated with varying concentrations of THZ1 or 10 µM THZ1-R for 4 hours. Cell lysates were then incubated with bio-THZ1, followed by immunoblotting and immunoprecipitation to detect CDK7 labeling and competitive binding. Result: Bio-THZ1 effectively pulled down CDK7, and THZ1 competed for binding in a dose-dependent manner. Immunoprecipitation confirmed that bio-THZ1 specifically labels CDK7, indicating that THZ1 covalently binds to intracellular CDK7. [1]
Synonyms	THZ1R

Chemical Properties

Molecular Weight	568.07
Formula	C₃₁H₃₀ClN₇O₂
Cas No.	1621523-07-6
Smiles	O=C(NC=1C=CC=C(C1)NC=2N=CC(Cl)=C(N2)C3=CNC=4C=CC=CC43)C5=CC=C(C=C5)NC(=O)CCCN(C)C
Relative Density.	1.362 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (140.83 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7603 mL	8.8017 mL	17.6035 mL	88.0173 mL
5 mM	0.3521 mL	1.7603 mL	3.5207 mL	17.6035 mL
10 mM	0.1760 mL	0.8802 mL	1.7603 mL	8.8017 mL
20 mM	0.0880 mL	0.4401 mL	0.8802 mL	4.4009 mL
50 mM	0.0352 mL	0.1760 mL	0.3521 mL	1.7603 mL
100 mM	0.0176 mL	0.0880 mL	0.1760 mL	0.8802 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc