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Mafenide Acetate

Name: Mafenide Acetate
Brand: TargetMol
SKU: T8122
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8122Cas No. 13009-99-9

Mafenide Acetate is a sulfonamide-type medication inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.

Mafenide Acetate

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Purity: 99.26%

Catalog No. T8122Cas No. 13009-99-9

Mafenide Acetate is a sulfonamide-type medication inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	-	In Stock
100 mg	$41	-	In Stock
500 mg	$78	-	In Stock
1 g	$107	-	In Stock
1 mL x 10 mM (in DMSO)	$32	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.26%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Mafenide Acetate AI Summary

Mafenide Acetate shows bioactivities such as inhibiting Human Jumonji Domain Containing 2E (JMJD2E), enhancing SMN2 splice variant expression, inhibiting Schistosoma Mansoni Peroxiredoxins, inhibiting HP1-beta chromodomain interactions with methylated histone tails, and inducing DNA re-replication in SW480 colon adenocarcinoma cells. Additionally, it demonstrates inhibitory activity in various transport assays involving human BSEP, MRP2, MRP3, and MRP4, with IC50 values greater than 133,000.0 nM, indicating a lack of significant inhibition. The compound does not show harmful bioactivities related to liver function, as all Hepatic Side Effect (HepSE) scores are 0.0 in liver-related assays according to the Drug Induced Liver Injury Prediction System (DILIps). Furthermore, Mafenide Acetate exhibits moderate antifungal activity against Candida albicans, mild to moderate antibacterial activity against strains such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, but not against Cryptococcus neoformans..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Mafenide Acetate is a sulfonamide-type medication inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.

Chemical Properties

Molecular Weight	246.29
Formula	C₉H₁₄N₂O₄S
Cas No.	13009-99-9
Smiles	CC(=O)O.NCc1ccc(S(N)(=O)=O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (243.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0603 mL	20.3013 mL	40.6025 mL	203.0127 mL
5 mM	0.8121 mL	4.0603 mL	8.1205 mL	40.6025 mL
10 mM	0.4060 mL	2.0301 mL	4.0603 mL	20.3013 mL
20 mM	0.2030 mL	1.0151 mL	2.0301 mL	10.1506 mL
50 mM	0.0812 mL	0.4060 mL	0.8121 mL	4.0603 mL
100 mM	0.0406 mL	0.2030 mL	0.4060 mL	2.0301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc