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Anti-Dectin-1 Antibody (8R553)
🥰Excellent
Catalog No. TMAY-03187
Anti-Dectin-1 Antibody (8R553) is a Rabbit antibody targeting Dectin-1. Anti-Dectin-1 Antibody (8R553) can be used in ICC/IF.
Anti-Dectin-1 Antibody (8R553)
Anti-Dectin-1 Antibody (8R553)
🥰Excellent
Catalog No. TMAY-03187
Anti-Dectin-1 Antibody (8R553) is a Rabbit antibody targeting Dectin-1. Anti-Dectin-1 Antibody (8R553) can be used in ICC/IF.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Dectin-1 Antibody (8R553) is a Rabbit antibody targeting Dectin-1. Anti-Dectin-1 Antibody (8R553) can be used in ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8R553 |
| Reactivity | Mouse |
| Verified Activity | Immunofluorescence staining of mouse Dectin-1 in Raw264.7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse Dectin-1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Dectin-1 / CLEC7A (rM Dectin-1 / CLEC7A; TMPY-01387; NP_064392.2; Phe69-Leu244). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse Dectin-1 / CLEC7A protein (TMPY-01387) |
| Antigen Species | Mouse |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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