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GLPG2534

Catalog No. T75113 CAS 2095615-97-5

Synonyms: GLPG-2534

GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis.

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GLPG2534, CAS 2095615-97-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 113.00
5 mg	In stock	$ 278.00
10 mg	In stock	$ 455.00
25 mg	In stock	$ 886.00
50 mg	In stock	$ 1,450.00
100 mg	In stock	$ 2,320.00

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Purity: 99.44%

Purity: 98.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis.
Targets&IC50	IL-1β:55 nM, IRAK1:179 nM, mIRAK4:3.5 nM, hIRAK4:6.4 nM
In vitro	GLPG2534 inhibits IL-6 release driven by IL-1β with an IC50 of 55 nM[1]. It also inhibits TNF-α-driven IL-6 release, with an IC50 of 6.6 μM[1]. When applied at concentrations ranging from 0.1 to 10 μM for 16 hours, GLPG2534 inhibits the expression of S100A7, DEFB4A, CXCL8, and TNF in ciliated epithelial cells stimulated with ciliogenesis-promoting factors[1].
In vivo	GLPG2534, administered orally at doses ranging from 0.3 to 10 mg/kg, inhibits CL097-driven TNF-α release in mouse blood[1]. Furthermore, oral administration of GLPG2534 at doses of 10 and 30 mg/kg, twice daily, alleviates inflammation in a psoriasis-like mouse model[1]. Additionally, GLPG2534, at doses of 3-30 mg/kg, orally administered twice daily for 5 days, mitigates the development of IL-33 and MC903-induced atopic dermatitis-like skin inflammation in mice[1].

Synonyms	GLPG-2534
Molecular Weight	424.45
Formula	C21H24N6O4
CAS No.	2095615-97-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (188.48 mM), Sonication is recommended.

References and Literature

1. Lavazais S, et al. IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases. Sci Transl Med. 2023 Feb 15;15(683):eabj3289.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

IRAK4-IN-1 IRAK4-IN-25 Thalidomide 4-fluoride IRAK4-IN-20 IRAK-4 protein kinase inhibitor 2 PROTAC IRAK4 degrader-8 IRAK inhibitor 1 IRAK4-IN-26

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GLPG2534 2095615-97-5 Immunology/Inflammation NF-Κb IRAK GLPG-2534 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.