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Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, blocking the interaction of LAG-3/MHC II (IC50: 0.67 nM) and LAG-3/FGL1 (IC50: 0.019 nM). Relatlimab is often used with Nivoluma to treat advanced melanoma.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 166.00 | |
5 mg | In stock | $ 535.00 | |
10 mg | In stock | $ 872.00 |
Description | Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, blocking the interaction of LAG-3/MHC II (IC50: 0.67 nM) and LAG-3/FGL1 (IC50: 0.019 nM). Relatlimab is often used with Nivoluma to treat advanced melanoma. |
In vitro |
Relatlimab (0.001-100 nM) recognizes native LAG-3 and binds to primary activated human and macaque CD4+ T cells with EC50 values of 0.11 nM and 29.11 nM, respectively.[1] Relatlimab (0.001-10000 nM; 3A9-hLAG-3) enhances peptide reactivity of T-cell hybridoma 3A9-hLAG-3 and reverses lag-3-mediated inhibition of T-cell hybridoma 3A9-hLAG-3 Effect, IC50 value is 1.05 nM.[1] Relatlimab (0.001-10000 nM; primary T cells) enhances activation and enhances IL-2 secretion in superantigen-stimulated human PBMC cultures.[1] |
Synonyms | BMS-986016 |
Molecular Weight | N/A |
CAS No. | 1673516-98-7 |
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Relatlimab 1673516-98-7 Others BMS986016 BMS 986016 BMS-986016 inhibitor inhibit