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Relatlimab (Synonyms: BMS-986016)
Catalog No. T9901A-001 Copy Product Info
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Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, blocking the interaction of LAG-3/MHC II (IC50: 0.67 nM) and LAG-3/FGL1 (IC50: 0.019 nM). Relatlimab is often used with Nivoluma to treat advanced melanoma.
Relatlimab
Copy Product Info🥰Excellent
Catalog No. T9901A-001
Synonyms BMS-986016
Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, blocking the interaction of LAG-3/MHC II (IC50: 0.67 nM) and LAG-3/FGL1 (IC50: 0.019 nM). Relatlimab is often used with Nivoluma to treat advanced melanoma.
Cas No. 1673516-98-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $166 | - | In Stock | |
| 5 mg | $535 | - | In Stock | |
| 10 mg | $872 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.8% (SDS-PAGE); 97.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, blocking the interaction of LAG-3/MHC II (IC50: 0.67 nM) and LAG-3/FGL1 (IC50: 0.019 nM). Relatlimab is often used with Nivoluma to treat advanced melanoma. |
| In vitro | Relatlimab (0.001-100 nM) recognizes native LAG-3 and binds to primary activated human and macaque CD4+ T cells with EC50 values of 0.11 nM and 29.11 nM, respectively.[1] Relatlimab (0.001-10000 nM; 3A9-hLAG-3) enhances peptide reactivity of T-cell hybridoma 3A9-hLAG-3 and reverses lag-3-mediated inhibition of T-cell hybridoma 3A9-hLAG-3 Effect, IC50 value is 1.05 nM.[1] Relatlimab (0.001-10000 nM; primary T cells) enhances activation and enhances IL-2 secretion in superantigen-stimulated human PBMC cultures.[1] |
| Synonyms | BMS-986016 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | LAG3/CD223 |
| Molecular Weight | 145.2 kDa |
| Cas No. | 1673516-98-7 |
| Relative Density. | no data available |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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