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AMG-529
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Catalog No. T9901A-968 Copy Product Info
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AMG-529 is a humanized monoclonal antibody targeting the asialoglycoprotein receptor 1 (ASGR1). Primarily expressed on hepatocytes, ASGR1 mediates the endocytosis and degradation of circulating asialoglycoproteins. AMG-529 functions by specifically binding to ASGR1 and blocking ligand interactions, thereby inhibiting receptor function. Clinical studies demonstrate that ASGR1 inhibition leads to a dose-dependent elevation in serum alkaline phosphatase (ALP) levels, which serves as a circulating biomarker for suppressed ASGR1 activity. This antibody is utilized in research concerning lipid metabolism regulation and cardiovascular protection mechanisms.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | AMG-529 is a humanized monoclonal antibody targeting the asialoglycoprotein receptor 1 (ASGR1). Primarily expressed on hepatocytes, ASGR1 mediates the endocytosis and degradation of circulating asialoglycoproteins. AMG-529 functions by specifically binding to ASGR1 and blocking ligand interactions, thereby inhibiting receptor function. Clinical studies demonstrate that ASGR1 inhibition leads to a dose-dependent elevation in serum alkaline phosphatase (ALP) levels, which serves as a circulating biomarker for suppressed ASGR1 activity. This antibody is utilized in research concerning lipid metabolism regulation and cardiovascular protection mechanisms. |
| In vitro | In biochemical assays, AMG-529 demonstrates high affinity for the extracellular domain of human ASGR1. In cell-based models, the antibody effectively blocks the binding and subsequent internalization of asialoglycoprotein ligands, preventing receptor-mediated endocytosis [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | ASGR1 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: AMG-529 chemical structure | AMG-529 in vitro
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