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NVP-ADW742

Name: NVP-ADW742
Brand: TargetMol
SKU: T6079
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6079Cas No. 475488-23-4

Alias ADW742, ADW

NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

NVP-ADW742

🥰Excellent

Purity: 98.70%

Catalog No. T6079Alias ADW742, ADWCas No. 475488-23-4

NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$85	In Stock
10 mg	$143	In Stock
25 mg	$297	In Stock
50 mg	$473	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Batch Information

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Purity:98.70%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
Targets&IC50	IGF-1R:0.17 μM
Synonyms	ADW742, ADW

Chemical Properties

Molecular Weight	453.58
Formula	C₂₈H₃₁N₅O
Cas No.	475488-23-4
Smiles	Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)C1CC(CN2CCCC2)C1
Relative Density.	1.31
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 10 mg/mL (22.04 mM), Heating is recommended.

Ethanol: 3 mg/mL (6.61 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2047 mL	11.0234 mL	22.0468 mL	110.2341 mL
5 mM	0.4409 mL	2.2047 mL	4.4094 mL	22.0468 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2205 mL	1.1023 mL	2.2047 mL	11.0234 mL
20 mM	0.1102 mL	0.5512 mL	1.1023 mL	5.5117 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc