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Anti-HRG/HPRG Antibody (1Q55) (Synonyms: histidine-rich glycoprotein)

Catalog No. TMAY-01241 Copy Product Info
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Anti-HRG/HPRG Antibody (1Q55) is a Rabbit antibody targeting HRG/HPRG. Anti-HRG/HPRG Antibody (1Q55) can be used in ELISA.

Anti-HRG/HPRG Antibody (1Q55)

Copy Product Info
🥰Excellent
Catalog No. TMAY-01241
Synonyms histidine-rich glycoprotein

Anti-HRG/HPRG Antibody (1Q55) is a Rabbit antibody targeting HRG/HPRG. Anti-HRG/HPRG Antibody (1Q55) can be used in ELISA.

Anti-HRG/HPRG Antibody
(1Q55)
Pack SizePriceUSA StockGlobal StockQuantity
100 μL$2697-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-HRG/HPRG Antibody (1Q55) is a Rabbit antibody targeting HRG/HPRG. Anti-HRG/HPRG Antibody (1Q55) can be used in ELISA.
Synonymshistidine-rich glycoprotein
Ig Type
Rabbit IgG
Clone
1Q55
Reactivity
Human
Specificity
Human HRG/HPRG
No cross-reactivity in ELISA with
Human CST3 / Cystatin-C / Cystatin-3
Human CST6 / Cystatin-E / Cystatin-6
Human Fetuin-A / AHSG
Application
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human HPRG (rhHPRG; TMPY-00979; Met 1-Lys 525; NP_000403.1).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundHistidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes, and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis, and the reduction of inhibition of coagulation indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally, and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human HPRG protein (TMPY-00979)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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