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7-O-Methylbiochanin A
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Catalog No. TN1333Cas No. 34086-51-6
Alias 4',7-Dimethoxy-5-hydroxyisoflavone
7-O-Methylbiochanin A (4',7-Dimethoxy-5-hydroxyisoflavone) is an isoflavone derivative isolated from the roots of Lotus polyphyllos and other plants in the water lily family.
7-O-Methylbiochanin A
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Purity: 99.00%
Catalog No. TN1333Alias 4',7-Dimethoxy-5-hydroxyisoflavoneCas No. 34086-51-6
7-O-Methylbiochanin A (4',7-Dimethoxy-5-hydroxyisoflavone) is an isoflavone derivative isolated from the roots of Lotus polyphyllos and other plants in the water lily family.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $60 | - | In Stock | |
| 5 mg | $143 | - | In Stock | |
| 10 mg | $213 | - | In Stock | |
| 25 mg | $353 | - | In Stock | |
| 50 mg | $513 | - | In Stock | |
| 100 mg | $708 | - | In Stock | |
| 200 mg | $953 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $150 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.00%
Appearance:Solid
Color:Yellow
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Product Introduction
7-O-Methylbiochanin A AI Summary
7-O-Methylbiochanin A demonstrates significant chemopreventive activity by inhibiting the metabolism of benzo[a]pyrene into water-soluble derivatives in Chinese hamster embryonic cells, with an ID50 value greater than 50.0 μg mL-1, indicating potential efficacy at high concentrations. Additionally, the compound exhibits a wide range of bioactivities across several assays:
- Modulates miRNAs/activates miR-21 with a potency of 826.0 nM.
- Activates the Rab9 promoter at 1000.0 nM.
- Enhances SMN2 splice variant expression at 12589.3 nM.
- Inhibits Menin-MLL interaction in MLL-related leukemias at 39810.7 nM.
- Activates the NPC1 promoter at 631.0 nM.
- Inhibits Nrf2 assay at 23109.3 nM.
- Inhibits chronic active B-cell receptor signaling at 1122.0 nM.
- Induces genotoxicity in HEK293T cells at 651.3 nM.
- Inhibits ELG1-dependent DNA repair in HEK293T cells at 8912.5 nM.
- Targets p450-cyp2d6 in a cytochrome panel assay at 35.48 nM.
- Inhibits malarial parasite plastid at 1651.1 nM, also delaying death in the parasite plastid at 1311.5 nM.
- Inhibits Polymerase Iota at 89125.1 nM.
- Inhibits Regulator of G Protein Signaling (RGS) 4 at 79432.8 nM.
- Inhibits binding or entry into cells for Lassa Virus at 1258.9 nM.
- Exhibits mixed inhibitory/activator activity on firefly luciferase at 1510.1 nM.
- Shows varied GI50 in inhibiting various human tumor cell lines.
Also, 7-O-Methylbiochanin A shows notable growth inhibition against human cancer cell lines SGC7901, HT-29, and HL60 with GI values of 7.78 uM, 4.18 uM, and 5.14 uM respectively per the MTT assay. It activates Nrf2 in mouse Heap1c1c7 cells by inducing NAD(P)H:quinone reductase activity at 25 uM and stabilizes Nrf2 in human BEAS2B cells by increasing its half-life to 0.46 hours when preincubated at 6.25 uM for 8 hours followed by CHX addition..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 7-O-Methylbiochanin A (4',7-Dimethoxy-5-hydroxyisoflavone) is an isoflavone derivative isolated from the roots of Lotus polyphyllos and other plants in the water lily family. |
| Synonyms | 4',7-Dimethoxy-5-hydroxyisoflavone |
| Molecular Weight | 298.29 |
| Formula | C17H14O5 |
| Cas No. | 34086-51-6 |
| Smiles | COc1ccc(cc1)-c1coc2cc(OC)cc(O)c2c1=O |
| Relative Density. | 1.321 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 6.25 mg/mL (20.95 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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