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BMS-986176

Name: BMS-986176
Brand: TargetMol
SKU: T35856
Price: 175 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35856Cas No. 1815613-42-3

Alias LX-9211

AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).

BMS-986176

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Purity: 98.7%

Catalog No. T35856Alias LX-9211Cas No. 1815613-42-3

AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$175	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$556	In Stock	In Stock
25 mg	$896	In Stock	In Stock
50 mg	$1,220	In Stock	In Stock
100 mg	$1,650	In Stock	In Stock
500 mg	$6,339	-	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.7%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
Targets&IC50	AAK1:2.2 nM
In vitro	AAK1-IN-1can be used for neurodegenerative disease studies. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases and modulates clatherin coated endocytosis. and receptor-mediated endocytosis[1].
Synonyms	LX-9211

Chemical Properties

Molecular Weight	385.4
Formula	C₁₉H₂₃F₄N₃O
Cas No.	1815613-42-3
Smiles	CC(C)C[C@](C)(N)COc1ccc(nc1C(F)F)-c1ccnc(c1)C(F)F
Relative Density.	1.188 g/cm3 (Predicted)
Color	Brown
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 220 mg/mL (570.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (12.97 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5947 mL	12.9735 mL	25.9471 mL	129.7353 mL
5 mM	0.5189 mL	2.5947 mL	5.1894 mL	25.9471 mL
10 mM	0.2595 mL	1.2974 mL	2.5947 mL	12.9735 mL
20 mM	0.1297 mL	0.6487 mL	1.2974 mL	6.4868 mL
50 mM	0.0519 mL	0.2595 mL	0.5189 mL	2.5947 mL
100 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2974 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc